Results 101 to 110 of about 5,678,918 (297)

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. [PDF]

PLoS ONE, 2008
The determination of left/right body axis during early embryogenesis sets up a developmental cascade that coordinates the development of the viscera and is essential to the correct placement and alignment of organ systems and vasculature.
Anna-Katerina Hadjantonakis, Elinor Pisano, Virginia E Papaioannou   +2 more
doaj   +1 more source

The Link Between TGF‐β Signaling and Chromatin Dynamics Takes an Unexpected Path

BioEssays, EarlyView.
A recent study uncovered a novel mechanism by which Tgfbr1 regulates morphogenesis: not by directly controlling the expression of genes regulating cell fate but by globally modulating chromatin accessibility, thus determining which enhancers are available to other morphogenetic factors, ultimately enabling the activation of specific developmental ...
Moises Mallo
wiley   +1 more source

Ca²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics. [PDF]

PLoS ONE, 2013
: Ca(2+)-activated basal adenylate cyclase (AC) in rabbit sinoatrial node cells (SANC) guarantees, via basal cAMP/PKA-calmodulin/CaMKII-dependent protein phosphorylation, the occurrence of rhythmic, sarcoplasmic-reticulum generated, sub-membrane Ca(2 ...
Yael Yaniv, Harold A Spurgeon, Bruce D Ziman, Edward G Lakatta   +3 more
doaj   +1 more source

Identification of Essential Proteins Using Induced Stars in Protein-Protein Interaction Networks [PDF]

arXiv, 2017
In this work, we propose a novel centrality metric, referred to as star centrality, which incorporates information from the closed neighborhood of a node, rather than solely from the node itself, when calculating its topological importance. More specifically, we focus on degree centrality and show that in the complex protein-protein interaction ...
arxiv  

Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]

, 2005
Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv   +1 more source

Extranodal diffuse large B‐cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study

Cancer Communications, EarlyView.
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of aggressive non‐Hodgkin's lymphoma with distinct clinical and molecular heterogeneity. DLBCL that arises in extranodal organs is particularly linked to poor prognosis. This study aimed to determine the clinical and molecular characteristics of extranodal involvement (
Si‐Yuan Chen, Peng‐Peng Xu, Ru Feng, Guo‐Hui Cui, Li Wang, Shu Cheng, Rong‐Ji Mu, Hui‐Lai Zhang, Xiao‐Lei Wei, Yong‐Ping Song, Kai‐Yang Ding, Li‐Hua Dong, Zun‐Min Zhu, Shen‐Miao Yang, Xin Wang, Ting‐Bo Liu, Jian‐Da Hu, Xiao‐Yun Zheng, Ou Bai, Jing‐Yan Xu, Liang Huang, Wei Sang, Ke‐Qian Shi, Fan Zhou, Fei Li, Ai‐Bin Liang, Hui Zhou, Si‐Guo Hao, Hong‐Hui Huang, Bin Xu, Wen‐Bin Qian, Cai‐Xia Li, Zhi‐Ming Li, Chong‐Yang Wu, Xiao‐Bo Wang, Wen‐Yu Shi, Shu‐Ye Wang, Yu‐Yang Tian, Xi Zhang, Ke‐Shu Zhou, Li‐Juan Cui, Hui Liu, Huo Tan, Qing Leng, Dong‐Lu Zhao, Ting Niu, Wei‐Li Zhao   +46 more
wiley   +1 more source

Why aren't the small worlds of protein contact networks smaller [PDF]

arXiv, 2011
Computer experiments are performed to investigate why protein contact networks (networks induced by spatial contacts between amino acid residues of a protein) do not have shorter average shortest path lengths in spite of their importance to protein folding.
arxiv  

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.

Cardiovascular Research, 2016
CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability,
Olurotimi O. Mesubi, M. Anderson
semanticscholar   +1 more source