Results 101 to 110 of about 65,866 (271)

Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

Journal of Pharmaceutical Analysis
Hyaluronan and proteoglycan link protein 1 (Hapln1) supports active cardiomyogenesis in zebrafish hearts, but its regulation in mammal cardiomyocytes is unclear.
Ding-Jun Hao, Yue Qin, Shi-Jie Zhou, Bu-Huai Dong, Jun-Song Yang, Peng Zou, Li-Ping Wang, Yuan-Ting Zhao   +7 more
doaj   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Detection of prognostic factors in metastatic breast cancer

Journal of Research in Medical Sciences, 2013
Background: The aim of this study was to detect prognostic factors in recurrent breast cancer metastasis. Materials and Methods: This retrospective cohort study employed data from 996 breast cancer patients of Isfahan Seyed-o-Shohada research center from
Mehdi Tazhibi, Mahsa Fayaz, Fariborz Mokarian   +2 more
doaj  

Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy

Frontiers in Immunology
IntroductionIn autoimmune nodopathies, autoantibodies target the nodes of Ranvier, impairing saltatory nerve conduction. Understanding the impact of autoantibody binding on protein assembly is crucial for gaining insights into the pathogenicity of ...
Vinicius da Cruz Neris Geßner, Vinicius da Cruz Neris Geßner, Janis Theobald Linke, Janis Theobald Linke, Thomas-Otavio Peulen, Luise Appeltshauser, Claudia Sommer, Dirk Brämer, Christian Geis, Katrin Gertrud Heinze, Kathrin Doppler   +10 more
doaj   +1 more source

Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases

Neoplasia: An International Journal for Oncology Research, 2018
Patients with metastatic prostate cancer (PCa) have a poorer prognosis than patients with organ-confined tumors. We strove to uncover the proteome signature of primary PCa and associated lymph node metastases (LNMs) in order to identify proteins that may
Ann-Kathrin Müller, Melanie Föll, Bianca Heckelmann, Selina Kiefer, Martin Werner, Oliver Schilling, Martin L. Biniossek, Cordula Annette Jilg, Vanessa Drendel   +8 more
doaj   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

A Review of Metal–Organic Framework (MOF) Based Active Food Packaging: Materials Selection, Cellulose Matrices Current Advances, Synthesis and Characterizations

Packaging Technology and Science, EarlyView.
Active packaging offers an effective approach to extending food shelf life. This review summarizes the past decade of progress in metal‐organic framework (MOF)‐based active food packaging, highlighting material selection, characterization, challenges, and future prospects.
Belladini Lovely, Young‐Teck Kim, Haibo Huang, Novitri Hastuti, Su Jung Hong   +4 more
wiley   +1 more source

Genetic variability, heritability and genetic advance for yield and yield components in sunflower (Helianthus annuus L.). [PDF]

Electronic Journal of Plant Breeding, 2012
Ten genotypes of sunflower were evaluated in the field following a randomized complete block design with three replications forplant height, stem diameter at base, inter nodal length, head diameter, number of whorls per head, achene weight per head ...
S.M. Fida Hassan1, *Muhammad Shahid Iqbal 2, Ghulam Rabbani1, Naeem-ud-Din1and Ghulam Shabbir
doaj  

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

VIEW, EarlyView.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi, B. W. M. Thilini J. Basnayake, Omar Breik, Lizbeth Kenny, Sarju Vasani, Riccardo Dolcetti, Chamindie Punyadeera   +6 more
wiley   +1 more source

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source