Results 111 to 120 of about 65,866 (271)

Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy

Frontiers in Cell and Developmental Biology
IntroductionProper placentation is essential for fetal growth and development in mammals. Nodal signaling is essential to ensure proper embryo development and requires Cripto-1 as a co-receptor.
Laura Girardet, Laura Girardet, Neha Kamath, Neha Kamath, Daniel Dufort, Daniel Dufort   +5 more
doaj   +1 more source

Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones

The Journal of Dermatology, EarlyView.
ABSTRACT Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity.
Ryoma Honda, Toshihisa Hamada, Makoto Sugaya   +2 more
wiley   +1 more source

Sodium channel Na_v1.6 accumulates at the site of infraorbital nerve injury

BMC Neuroscience, 2007
Background Sodium channel (NaCh) expressions change following nerve and inflammatory lesions and this change may contribute to the activation of pain pathways. In a previous study we found a dramatic increase in the size and density of NaCh accumulations,
Johnson Lonnie R, Freking Angelique R, Henry Michael A, Levinson S Rock   +3 more
doaj   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 Promoter

Developmental Biology, 1997
The Xenopus nodal-related 3 gene (Xnr3) is expressed in the Spemann organizer of the embryo and encodes a member of the transforming growth factor beta family that mediates some activities of the organizer. Xnr3 is transcriptionally activated by wnt signaling during gastrulation in the Xenopus embryo.
McKendry, Roslyn, Hsu, Shu-Chi, Harland, Richard M., Grosschedl, Rudolf   +3 more
openaire   +2 more sources

USP44, ZNF454, and GPRC5B ctDNA Methylation Markers in Breast Cancer: Limited Clinical Relevance for Disease Monitoring and Tumor Characteristics

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We selected breast cancer‐specific DNA methylation markers using The Cancer Genome Atlas (TCGA). We analyzed the methylation and expression patterns of candidate genes in breast cancer cell lines, ctDNA, and tissue samples. The relationship between ctDNA methylation markers and the clinicopathological features of breast cancer patients was investigated.
Young Ju Jeong, Chang‐Ho Jeon, Hoon Kyu Oh, Jeong Kyu Kim, Chun‐Seok Yang, Na‐Rang Lee, Doyeon Kim   +6 more
wiley   +1 more source

Proteomic profile of human sinoatrial and atrioventricular nodes in comparison to working myocardium

Scientific Reports
The proteomic profile of the human cardiac conduction system: the sinoatrial node (SAN) and atrioventricular node (AVN), remains poorly understood. The aim of the current study is to identify proteomic characteristic of the human SAN and AVN in the ...
Agata Krawczyk-Ożóg, Aneta Stachowicz, Grzegorz Szoniec, Jakub Batko, Kamila Stachyra, Filip Bolechała, Marcin Strona, Paweł P. Wołkow, Zeyuan Yin, Halina Dobrzynski, Mateusz K. Hołda   +10 more
doaj   +1 more source

Molecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts

Frontiers in Neurology, 2017
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles.
Hamza Coban, Spencer Tung, Bryan Yoo, Harry V. Vinters, Harry V. Vinters, Jason D. Hinman   +5 more
doaj   +1 more source

Protein-Losing Enteropathy in a Case of Nodal Follicular Lymphoma without a Gastrointestinal Mucosal Lesion

Internal Medicine, 2008
Protein-losing enteropathy (PLE) is characterized by gastrointestinal loss of serum protein. It is usually caused by hypersecretion from a tumor, ulcer, or long standing lymphangiectasia. However, we report a 47-year-old man of peritoneal nodal follicular lymphoma who developed PLE with none of them.
Hiroto, Kaneko, Mihoko, Yamashita, Muneo, Ohshiro, Yasuo, Ohkawara, Yosuke, Matsumoto, Kenichi, Nomura, Shigeo, Horiike, Shouhei, Yokota, Masafumi, Taniwaki   +8 more
openaire   +3 more sources

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source