Results 151 to 160 of about 5,678,918 (297)

BRD9 inhibition as potential treatment option for testicular germ cell tumors

open access: yesAndrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen   +5 more
wiley   +1 more source

Molecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts

open access: yesFrontiers in Neurology, 2017
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles.
Hamza Coban   +5 more
doaj   +1 more source

Combination of fixed low‐dose nivolumab and bendamustine in children with high‐risk relapsed/refractory classical Hodgkin lymphoma

open access: yesBritish Journal of Haematology, EarlyView.
A retrospective study of 18 pediatric patients with high‐risk relapsed/refractory classical Hodgkin lymphoma demonstrated that a fixed low‐dose combination of nivolumab and bendamustine achieved an 88% complete response rate, with 1‐year progression‐free survival (PFS) of 88.2% and overall survival (OS) of 94.4%.
Shyam Srinivasan   +12 more
wiley   +1 more source

Counting nodal domains [PDF]

open access: yesarXiv, 2003
We consider the nodal domains of Gaussian random waves in two dimensions. We present a method to calculate the distribution of the number of nodal domains and the average connectivity with the help of auxiliary Potts-spins. An analytical approach could be helpful to decide whether the pattern of nodal domains belongs to the universality class of short ...
arxiv  

Impact of concomitant carcinoma in situ distribution on non‐muscle‐invasive bladder cancer progression risk

open access: yesBJU International, EarlyView.
Objective To assess whether the distribution of concomitant carcinoma in situ (CIS; unifocal or multifocal) with papillary non‐muscle‐invasive bladder cancer (NMIBC) impacts the risk of progression, as concomitant CIS is an established risk factor for progression in papillary NMIBC and commonly used calculators do not make this distinction.
Jethro C.C. Kwong   +22 more
wiley   +1 more source

Genetic Profiling Reveals the Distinctions Among MTX‐Associated DLBCL, EBV‐Positive Mucocutaneous Ulcer, and EBV + DLBCL

open access: yesCancer Science, EarlyView.
EBV‐ MTX‐DLBCL shows higher driver gene mutation rates and worse outcomes after MTX discontinuation compared to EBV+ MTX‐DLBCL. IDD‐LPDs have lower mutation rates in genes related to clonal hematopoiesis (TET2/DNMT3A) and immune evasion (CD58) compared to EBV + DLBCL. ABSTRACT The WHO recently changed the outline of immunodeficiency/dysregulation (IDD)‐
Takumi Takahashi   +12 more
wiley   +1 more source

Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells

open access: yesCell Proliferation, EarlyView.
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei   +9 more
wiley   +1 more source

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