Results 151 to 160 of about 5,678,918 (297)
BRD9 inhibition as potential treatment option for testicular germ cell tumors
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen+5 more
wiley +1 more source
Molecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles.
Hamza Coban+5 more
doaj +1 more source
Flow cytometric evaluation of multidrug resistance proteins on grossly normal canine nodal lymphocyte membranes [PDF]
Stephanie E. Schleis+3 more
openalex +1 more source
A retrospective study of 18 pediatric patients with high‐risk relapsed/refractory classical Hodgkin lymphoma demonstrated that a fixed low‐dose combination of nivolumab and bendamustine achieved an 88% complete response rate, with 1‐year progression‐free survival (PFS) of 88.2% and overall survival (OS) of 94.4%.
Shyam Srinivasan+12 more
wiley +1 more source
We consider the nodal domains of Gaussian random waves in two dimensions. We present a method to calculate the distribution of the number of nodal domains and the average connectivity with the help of auxiliary Potts-spins. An analytical approach could be helpful to decide whether the pattern of nodal domains belongs to the universality class of short ...
arxiv
Ablation of Protein Kinase A or Calmodulin Kinase II Phosphorylation Sites on Phospholamban Confer Arrhythmia Resistance in Sinoatrial Nodal Pacemaker Cells [PDF]
Yuejin Wu, Mark E. Anderson
openalex +1 more source
Objective To assess whether the distribution of concomitant carcinoma in situ (CIS; unifocal or multifocal) with papillary non‐muscle‐invasive bladder cancer (NMIBC) impacts the risk of progression, as concomitant CIS is an established risk factor for progression in papillary NMIBC and commonly used calculators do not make this distinction.
Jethro C.C. Kwong+22 more
wiley +1 more source
EBV‐ MTX‐DLBCL shows higher driver gene mutation rates and worse outcomes after MTX discontinuation compared to EBV+ MTX‐DLBCL. IDD‐LPDs have lower mutation rates in genes related to clonal hematopoiesis (TET2/DNMT3A) and immune evasion (CD58) compared to EBV + DLBCL. ABSTRACT The WHO recently changed the outline of immunodeficiency/dysregulation (IDD)‐
Takumi Takahashi+12 more
wiley +1 more source
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei+9 more
wiley +1 more source
CA2+ Cycling Proteins Phosphorylation in Isolated Sinoatrial Nodal Cells Modulates the Stochasticity of Spontaneous Diastolic Local CA2+ Releases which Regulate the Action Potential Cycle Length and its Beat-To-Beat Variation [PDF]
Dongmei Yang+3 more
openalex +1 more source