Advances in the Study of Pluripotent Stem Cells in Livestock
Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou+6 more
wiley +1 more source
Intelligent Manufacturing for Osteoarthritis Organoids
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley +1 more source
Global protein function prediction in protein-protein interaction networks [PDF]
The determination of protein functions is one of the most challenging problems of the post-genomic era. The sequencing of entire genomes and the possibility to access gene's co-expression patterns has moved the attention from the study of single proteins or small complexes to that of the entire proteome. In this context, the search for reliable methods
arxiv
Supplementary Tables 1-3, Figure Legends 1-2 from Embryonic Protein Nodal Promotes Breast Cancer Vascularization [PDF]
Daniela F. Quail+10 more
openalex +1 more source
The evolving role of positron emission tomography in precision prostate cancer biopsy
Prostate biopsy plays a pivotal role in the detection and characterization of prostate cancer. PSMA PET‐targeted biopsy represents a significant advancement in prostate cancer diagnostics, offering higher sensitivity, specificity and accuracy in detecting clinically significant lesions compared to traditional methods. PSMA PET, when combined with mpMRI,
Alessio Imperiale+11 more
wiley +1 more source
Lymphomatoid Papulosis Following Spesolimab Treatment for Generalised Pustular Psoriasis
Australasian Journal of Dermatology, EarlyView.
Mizuho Namba+6 more
wiley +1 more source
In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik+5 more
wiley +1 more source
Supplementary Figure 1 from MSH3 Protein Expression and Nodal Status in MLH1-Deficient Colorectal Cancers [PDF]
Luigi Laghi+10 more
openalex +1 more source
Epigenetic control of cell identities from epiblast to gastrulation
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley +1 more source
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara+9 more
wiley +1 more source