Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes [PDF]
Neoplasia: An International Journal for Oncology Research, 2021 The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cells ...
Dylan Dieters-Castator +15 more
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Ca²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics. [PDF]
PLoS ONE, 2013 : Ca(2+)-activated basal adenylate cyclase (AC) in rabbit sinoatrial node cells (SANC) guarantees, via basal cAMP/PKA-calmodulin/CaMKII-dependent protein phosphorylation, the occurrence of rhythmic, sarcoplasmic-reticulum generated, sub-membrane Ca(2 ...
Yael Yaniv +3 more
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Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to γδ T Cell Cytotoxicity [PDF]
Frontiers in Immunology, 2020 Gamma delta (γδ) T cells kill transformed cells, and increased circulating γδ T cells levels correlate with improved outcome in cancer patients; however, their function within the breast tumor microenvironment (TME) remains controversial.
Gabrielle M. Siegers +6 more
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Supplementary Methods from Embryonic Protein Nodal Promotes Breast Cancer Vascularization [PDF]
, 2023 <p>PDF file - 153K</p>
Daniela F. Quail +10 more
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Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2020 Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barre syndrome (GBS) or chronic ...
Désirée De Simoni +23 more
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MSH3 Protein Expression and Nodal Status in MLH1-Deficient Colorectal Cancers [PDF]
Clinical Cancer Research, 2012 Abstract Purpose: Patients with colorectal cancers (CRC) and high microsatellite instability (MSI) have a better outcome than their chromosome-unstable counterpart. Given the heterogeneity of microsatellite-unstable CRCs, we wanted to see whether any MSI-associated molecular features are specifically associated with prognosis.
Luigi Laghi +10 more
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Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells [PDF]
Biology Open, 2018 Despite recent progress in melanoma therapy via inhibition of activated oncogenes or immune stimulation, most stage IV melanoma patients still have limited survival times.
Tobias Sinnberg +5 more
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Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis.
PLoS ONE, 2011 IntroductionYes-associated protein (YAP) is considered an oncogene found amplified in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, the role for YAP expression in HNSCC is not understood.
Lin Ge +8 more
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Production in Bacteria and Characterization of Engineered Humanized Fab Fragment against the Nodal Protein. [PDF]
Pharmaceuticals (Basel), 2023 Drug development in recent years is increasingly focused on developing personalized treatments based on blocking molecules selective for therapeutic targets specifically present in individual patients. In this perspective, the specificity of therapeutic targets and blocking agents plays a crucial role.
Sivaccumar JP +7 more
europepmc +5 more sources
Two Modes by which Lefty Proteins Inhibit Nodal Signaling [PDF]
Current Biology, 2004 During vertebrate embryogenesis, members of the Lefty subclass of Transforming Growth Factor-beta (TGFbeta) proteins act as extracellular antagonists of the signaling pathway for Nodal, a TGFbeta-related ligand essential for mesendoderm formation and left-right patterning.
Canhe Chen, Michael M. Shen
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