Results 11 to 20 of about 5,678,918 (297)

Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2020
Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barre syndrome (GBS) or chronic ...
Désirée De Simoni, Gerda Ricken, Michael Winklehner, Inga Koneczny, Michael Karenfort, Ulf Hustedt, Ulrich Seidel, Omar Abdel‐Mannan, Pinki Munot, Simon Rinaldi, Claudia Steen, Michael Freilinger, Markus Breu, Rainer Seidl, Markus Reindl, Julia Wanschitz, Cinta Lleixà, G. Bernert, Klaus‐Peter Wandinger, Ralf Junker, Luís Querol, Frank Leypoldt, Kevin Rostásy, Romana Höftberger   +23 more
  +9 more sources

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2004
Before implantation in the uterus, mammalian embryos set aside trophoblast stem cells that are maintained in the extraembryonic ectoderm (ExE) during gastrulation to generate the fetal portion of the placenta.
Marcela Guzman-Ayala, Nadav Ben-Haim, Séverine Beck, Daniel B. Constam   +3 more
openalex   +2 more sources

The Pitx2 Homeobox Protein Is Required Early for Endoderm Formation and Nodal Signaling

Developmental Biology, 2001
Nodal and Nodal-related factors play fundamental roles in a number of developmental processes, including mesoderm and endoderm formation, patterning of the anterior neural plate, and determination of bilateral asymmetry in vertebrates. pitx2, a paired-like homeobox gene, has been proposed to act downstream of Nodal in the gene cascade providing ...
Marion Faucourt, Evelyn Houliston, Lydia Besnardeau, David Kimelman, Thierry Lepage   +4 more
openalex   +4 more sources

The effect of maternal NODAL on STOX1 expression in extravillous trophoblasts is mediated by IGF1. [PDF]

PLoS ONE, 2018
The number of molecules identified to be involved in communication between placenta and decidua is fast expanding. Previously, we showed that NODAL expressed in maternal endometrial stromal cells is able to affect NODAL and STOX1 expression in placental ...
Allerdien Visser, Maarten Beijer, Cees B M Oudejans, Marie van Dijk   +3 more
doaj   +2 more sources

Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer [PDF]

BMC Urology, 2013
BackgroundThe nodal status is a strong predictor for cancer specific death in patients with penile carcinoma, and the C-reactive protein (CRP) level at diagnosis has recently been shown to be associated with poor clinical outcome in various solid ...
A. Al Ghazal, S. Steffens, J. Steinestel, R. Lehmann, T. Schnoeller, Anna Schulte-Hostede, G. Wegener, F. Jentzmik, M. Schrader, M. Kuczyk, A. Schrader   +10 more
semanticscholar   +4 more sources

MSH3 Protein Expression and Nodal Status in MLH1-Deficient Colorectal Cancers [PDF]

Clinical Cancer Research, 2012
Abstract Purpose: Patients with colorectal cancers (CRC) and high microsatellite instability (MSI) have a better outcome than their chromosome-unstable counterpart. Given the heterogeneity of microsatellite-unstable CRCs, we wanted to see whether any MSI-associated molecular features are specifically associated with prognosis.
L. Laghi, P. Bianchi, G. Delconte, G. Celesti, G. Di Caro, M. Pedroni, A. Chiaravalli, B. Jung, C. Capella, M. P. de Leon, A. Malesci   +10 more
semanticscholar   +5 more sources

Nodal promotes invasive phenotypes via a Mitogen Activated Protein Kinase-dependent pathway [PDF]

Oncogene, 2013
The progression of cancer from localized to invasive disease is requisite for metastasis, and is often characterized by epithelial-to-mesenchymal transition (EMT) and alterations in cellular adhesion and migration. Studies have shown that this transition
D. Quail, Guihua Zhang, Scott D. Findlay, David A. Hess, L. Postovit   +4 more
semanticscholar   +5 more sources

Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish

Mechanisms of Development, 2000
In vertebrates, specification of the dorso-ventral axis requires Wnt signaling, which leads to formation of the Nieuwkoop center and the Spemann organizer (dorsal organizer), through the nuclear accumulation of beta-catenin. Zebrafish bozozok/dharma (boz) and squint (sqt), which encode a homeodomain protein and a Nodal-related protein, respectively ...
Takashi Shimizu, Yojiro Yamanaka, Seung-Lim Ryu, Hisashi Hashimoto, Taijiro Yabe, Tsutomu Hirata, Young‐Ki Bae, Masahiko Hibi, Toshio Hirano   +8 more
openalex   +4 more sources

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids.

PLoS Biology, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Sapna Chhabra, Lizhong Liu, Ryan Goh, Xiangyu Kong, Aryeh Warmflash   +4 more
doaj   +2 more sources

Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal Signaling [PDF]

Current Biology, 2002
The regulation of signaling pathways by feedback inhibitors has become an emerging theme in the control of pattern formation during development. Nodal and Lefty proteins belong to divergent subfamilies of the TGF-beta family. Nodal signals promote mesendoderm induction in vertebrates, and Lefty proteins antagonize it.
Yu Chen, Alexander F. Schier
openalex   +5 more sources