Results 241 to 250 of about 65,866 (271)

Monomeric mature protein of Nodal-related 3 activates Xbra expression

Development Genes and Evolution, 2006
Nodal and related proteins play central roles in axes formation, mesendoderm induction, neural patterning, and left-right development. However, Xenopus nodal-related 3 (Xnr3) has unique activities in regulating neural induction and convergent extension movements.
Yoshikazu, Haramoto, Shuji, Takahashi, Makoto, Asashima   +2 more
openaire   +2 more sources

Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling

Journal of Cell Science, 2011
The secreted protein Noggin1 is an embryonic inducer that can sequester TGFβ cytokines of the BMP family with extremely high affinity. Owing to this function, ectopic Noggin1 can induce formation of the headless secondary body axis in Xenopus embryos. Here, we show that Noggin1 and its homolog Noggin2 can also bind, albeit less effectively, to ActivinB,
Andrey V, Bayramov, Fedor M, Eroshkin, Natalia Y, Martynova, Galina V, Ermakova, Elena A, Solovieva, Andrey G, Zaraisky   +5 more
openaire   +2 more sources

Nodal andBone morphogenetic protein 5 interact in murine mesoderm formation and implantation

genesis, 2000
Mice mutant for the TGF-beta family member, nodal, lack mesoderm and die between E8.5 and E9.5. The short ear-lethal (se(l) ) mutation, a deletion that eliminates Bmp-5, causes a strikingly similar gastrulation defect. Here we analyze se(l);nodal compound mutants and find a dosage effect.
K C, Pfendler, J, Yoon, G U, Taborn, M R, Kuehn, P M, Iannaccone   +4 more
openaire   +2 more sources

Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer

PROTEOMICS, 2006
AbstractWe examined the proteomic background of esophageal cancer. We used laser microdissection to obtain tumor tissues from 72 esophageal squamous cell carcinoma cases and adjacent normal tissues in 57 of these cases. The 2D‐DIGE generated quantitative expression profiles with 1730 protein spots.
Hiromitsu, Hatakeyama, Tadashi, Kondo, Kiyonaga, Fujii, Yukihiro, Nakanishi, Hoichi, Kato, Satoshi, Fukuda, Setsuo, Hirohashi   +6 more
openaire   +2 more sources

The wheat proteins puroindoline-a and α1-purothionin induce nodal swelling in myelinated axons

NeuroReport, 1998
The effects of two basic cysteine-rich lipid-binding proteins isolated from wheat seedlings, puroindoline-a and alpha1-purothionin, were studied on single frog myelinated axons stained with the fluorescent dye FM1-43 using confocal laser scanning microscopy.
Mattei, César, Elmorjani, Khalil, Molgó, Jordi, Marion, Didier, Benoit, Evelyne   +4 more
openaire   +5 more sources

Influence of RGS6 on Inhibitory G Protein Signaling in Mouse Sinoatrial Nodal Cells

The FASEB Journal, 2020
Introduction M2 muscarinic (M 2 R) activation of G protein‐gated inwardly rectifying K + (GIRK) channels in sinoatrial nodal (SAN) cells is a key mediator of vagal/parasympathetic slowing of heart rate.
Allison Anderson, Ikuo Masuho, Ezequiel Marron, Kirill Martemyanov, Kevin Wickman   +4 more
openaire   +1 more source

Flow cytometric evaluation of multidrug resistance proteins on grossly normal canine nodal lymphocyte membranes

American Journal of Veterinary Research, 2008
Abstract Objective—To demonstrate efficacy of flow cytometric evaluation of expression and activity of P-glycoprotein (P-gp) and multidrug resistance–associated protein (MRP) efflux pumps and characterize and correlate their expression and activity in grossly normal canine nodal lymphocytes. Sample Population—Nodal lymphocytes from 21 clinically normal
Stephanie E, Schleis, Amy K, LeBlanc, Nancy R, Neilsen, Casey J, LeBlanc   +3 more
openaire   +2 more sources

Comparative Proteomics in Neurodegenerative and Non-neurodegenerative Diseases Suggest Nodal Point Proteins in Regulatory Networking

Journal of Proteome Research, 2006
Neurodegenerative disorders (ND) encompass clinically and genetically heterogeneous diseases with considerable overlap of their clinical, neuropathological and molecular phenotype. Various causes of neurodegeneration in disease may affect eventually the same proteins within protein networks.
Claus, Zabel, Dijana, Sagi, Angela M, Kaindl, Nicole, Steireif, Yvonne, Kläre, Lei, Mao, Hartmut, Peters, Maik A, Wacker, Ralf, Kleene, Joachim, Klose   +9 more
openaire   +2 more sources

Bcl-2 protein expression correlates with nodal status in non small cell lung cancer.

Anticancer research, 1999
We investigated the immunohistochemical expression of bcl-2 in 55 non small cell lung cancer patients in order to understand if the altered expression of this gene is involved in the development of this kind of neoplasm. Our results showed bcl-2 immunopositivity to be a frequent event in non small cell lung cancer (54.5%) with a higher expression in ...
GROEGER AM, CAPUTI M, ESPOSITO V, DE LUCA, Antonio, SALAT A, MURABITO M, GIORDANO GG, BALDI F, GIORDANO A, WOLNER E.   +9 more
openaire   +3 more sources

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly