Results 31 to 40 of about 65,866 (271)

Amyloid precursor protein at node of Ranvier modulates nodal formation [PDF]

Cell Adhesion & Migration, 2014
Amyloid precursor protein (APP), commonly associated with Alzheimer disease, is upregulated and distributes evenly along the injured axons, and therefore, also known as a marker of demyelinating axonal injury and axonal degeneration. However, the physiological distribution and function of APP along myelinated axons was unknown.
De-En, Xu, Wen-Min, Zhang, Zara Zhuyun, Yang, Hong-Mei, Zhu, Ke, Yan, Shao, Li, Dominique, Bagnard, Gavin S, Dawe, Quan-Hong, Ma, Zhi-Cheng, Xiao   +9 more
openaire   +2 more sources

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation [PDF]

Journal of Cell Biology
The ER relies on membrane-shaping proteins to maintain a continuous network of sheets and tubules that host distinct biological processes. How this intricate structure of the ER membrane system is maintained under conditions of mechanical strain is incompletely understood.
Brigitte S. Naughton, Swapnil C. Devarkar, Vanessa Todorow, Sunanda Mallik, Stacey Oxendine, Sanjana Junnarkar, Yuan Ren, Julien Berro, Janine Kirstein, Yong Xiong, Christian Schlieker   +10 more
openalex   +2 more sources

The effect of maternal NODAL on STOX1 expression in extravillous trophoblasts is mediated by IGF1. [PDF]

PLoS ONE, 2018
The number of molecules identified to be involved in communication between placenta and decidua is fast expanding. Previously, we showed that NODAL expressed in maternal endometrial stromal cells is able to affect NODAL and STOX1 expression in placental ...
Allerdien Visser, Maarten Beijer, Cees B M Oudejans, Marie van Dijk   +3 more
doaj   +1 more source

Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism

Cell Reports, 2020
Summary: Opposing sources of bone morphogenetic protein (BMP) and Nodal signaling molecules are sufficient to induce the formation of a full axis in zebrafish embryos.
Gary Huiming Soh, Autumn Penecilla Pomreinke, Patrick Müller   +2 more
doaj   +1 more source

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

European Urology Open Science, 2021
Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively. Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis. Design, setting, and participants: We
Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung   +17 more
doaj   +1 more source

Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal Signaling [PDF]

Current Biology, 2002
The regulation of signaling pathways by feedback inhibitors has become an emerging theme in the control of pattern formation during development. Nodal and Lefty proteins belong to divergent subfamilies of the TGF-beta family. Nodal signals promote mesendoderm induction in vertebrates, and Lefty proteins antagonize it.
Chen, Yu, Schier, Alexander F.
openaire   +3 more sources

Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway [PDF]

Oncogene, 2013
The progression of cancer from localized to invasive disease is requisite for metastasis, and is often characterized by epithelial-to-mesenchymal transition (EMT) and alterations in cellular adhesion and migration. Studies have shown that this transition is associated with an upregulation of embryonic stem cell-associated genes, resulting in a ...
Quail, D. F., Zhang, G., Findlay, S. D., Hess, D. A., Postovit, L. M.   +4 more
openaire   +4 more sources

Embryonic morphogen nodal is associated with progression and poor prognosis of hepatocellular carcinoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Nodal, a TGF-β-related embryonic morphogen, is involved in multiple biologic processes. However, the expression of Nodal in hepatocellular carcinoma (HCC) and its correlation with tumor angiogenesis, epithelial-mesenchymal transition, and ...
Jing Chen, Wen-Bin Liu, Wei-Dong Jia, Ge-Liang Xu, Jin-Liang Ma, Yun Ren, Hao Chen, Si-Nan Sun, Mei Huang, Jian-Sheng Li   +9 more
doaj   +1 more source

Factors correlating with lymph node metastases in patients with T1 ductal invasive breast cancer [PDF]

Archive of Oncology, 2006
BACKGROUND: Identification of reliable predictors of axillary lymph node metastases (ALNM) may be useful in selecting appropriate management for patients with T1-size breast cancer.
Ivković-Kapicl Tatjana, Panjković Milana, Ninčić Dejan, Knežević-Ušaj Slavica   +3 more
doaj   +1 more source

The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities [PDF]

Development, 2008
Nodal proteins are secreted signaling factors of the transforming growth factor β (TGFβ) family with essential roles in embryonic development in vertebrates. Mutations affecting the Nodal factors have severe consequences in mammals and fish. Furthermore, increased Nodal levels have been associated with melanoma tumor progression.
Jing Tian, Birgit Andrée, C. Michael Jones, Karuna Sampath   +3 more
openalex   +4 more sources