Results 61 to 70 of about 5,678,918 (297)

Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis [PDF]

Brain, 2006
Saltatory conduction in myelinated fibres depends on the specific molecular organization of highly specialized axonal domains at the node of Ranvier, the paranodal and the juxtaparanodal regions. Voltage-gated sodium channels (Na(v)) have been shown to be deployed along the naked demyelinated axon in experimental models of CNS demyelination and in ...
Irène Coman, Catherine Lubetzki, Catherine Lubetzki, Jean-Antoine Girault, Jean-Antoine Girault, Richard Reynolds, Bernard Zalc, Bernard Zalc, Marie-Stéphane Aigrot, Marie-Stéphane Aigrot, Danielle Seilhean   +10 more
openaire   +3 more sources

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Topological nodal chains in optical lattices [PDF]

PRA 103, 033316 (2021), 2021
Topological nodal rings as the simplest topological nodal lines recently have been extensively studied in optical lattices. However, the realization of complex nodal line structures like nodal chains in this system remains a crucial challenge. Here we propose an experimental scheme to realize and detect topological nodal chains in optical Raman ...
arxiv   +1 more source

Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

Nature Communications, 2020
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2 is crucial for flow sensing.
M. Maerker, Maike Getwan, Megan E. Dowdle, Jason C. McSheene, Vanessa Gonzalez, Jose L Pelliccia, Danielle S. Hamilton, V. Yartseva, Charles E. Vejnar, Melanie Tingler, Katsura Minegishi, Philipp Vick, Antonio J. Giráldez, H. Hamada, R. Burdine, M. Sheets, M. Blum, A. Schweickert   +17 more
semanticscholar   +1 more source

Engineering second-order nodal-line semimetals by breaking $\mathcal{PT}$ symmetry and periodic driving [PDF]

Phys. Rev. B 107, 035128 (2023), 2022
Hosting unique drumhead surface states enclosed by nodal lines, topological nodal-line semimetals exhibit novel transport phenomena. Thus, the exploration of topological semimetals with different nodal-line structures has attracted much attention. In this paper, we first find a second-order nodal line semimetal (SONLS), which has coexisting hinge Fermi
arxiv   +1 more source

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.

PLoS Genetics, 2016
During mammalian development, left-right (L-R) asymmetry is established by a cilia-driven leftward fluid flow within a midline embryonic cavity called the node.
Daniel T Grimes, Jennifer L Keynton, Maria T Buenavista, Xingjian Jin, Saloni H Patel, Shinohara Kyosuke, Jennifer Vibert, Debbie J Williams, Hiroshi Hamada, Rohanah Hussain, Surya M Nauli, Dominic P Norris   +11 more
doaj   +1 more source

Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to γδ T Cell Cytotoxicity

Frontiers in Immunology, 2020
Gamma delta (γδ) T cells kill transformed cells, and increased circulating γδ T cells levels correlate with improved outcome in cancer patients; however, their function within the breast tumor microenvironment (TME) remains controversial.
Gabrielle M. Siegers, Indrani Dutta, Eun Young Kang, Jing Huang, Martin Köbel, Lynne-Marie Postovit, Lynne-Marie Postovit   +6 more
doaj   +1 more source

Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons [PDF]

eLife, 2021
Voltage-gated sodium channels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conduction in vertebrate nerves. Node assembly in peripheral nerves is thought to be initiated at heminodes at the extremities of myelinating Schwann cells, and fusion of heminodes results in the establishment of nodes. Here we show that
Elise LV Malavasi, Aniket Ghosh, Daniel G Booth, Michele Zagnoni, Diane L Sherman, Peter J Brophy   +5 more
openaire   +6 more sources

Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta

Frontiers in Genetics, 2013
Nodal, a secreted signaling protein from the TGFβ-super family plays a vital role during early embryonic development. Recently, it was found that maternal decidua-specific Nodal knockout mice show intrauterine growth restriction (IUGR) and preterm birth.
Hari Krishna Thulluru, Craig ePark, Daniel eDufort, Gunilla eKleiverda, Cees eOudejans, Marie eVan Dijk   +5 more
doaj   +1 more source

GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Mechanisms promoting the compartmentalization of G-protein signaling are poorly understood in native cells. This study examined muscarinic (M2R) and adenosine (A1R) receptor signaling to a common effector—the G protein-gated inwardly ...
Allison Anderson, I. Masuho, Ezequiel Marron Fernandez de Velasco, A. Nakano, L. Birnbaumer, K. Martemyanov, K. Wickman   +6 more
semanticscholar   +1 more source