Results 71 to 80 of about 130,518 (256)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Distributed hue recognition based k connectivity path detection in WSN
Dianxin kexue, 2018 In order to improve the accuracy of k connectivity path detection algorithm in wireless sensor network (WSN),a k connectivity path detection algorithm based on distributed hue recognition for WSN was proposed.Firstly,the model structure of the WSN ...
Shihua CAO +3 more
doaj +2 more sources
Definite quadrature formulae of 5-th order with equidistant nodes
Annual of Sofia University St. Kliment Ohridski. Faculty of Mathematics and Informatics, 2019 We construct sequences of definite quadrature formulae of order five which use equidistant nodes. The error constants of these quadratures are evaluated and simple a posteriori error estimates derived under the assumption that the integrand's fifth derivative does not change its sign in the integration interval.
Ana Avdzhieva, Geno Nikolov
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Underestimated Cost of Targeted Attacks on Complex Networks
Complexity, 2018 The robustness of complex networks under targeted attacks is deeply connected to the resilience of complex systems, which is defined as the ability to make appropriate response to the attack. In this paper, we study robustness of complex networks under a
Xiao-Long Ren +3 more
doaj +1 more source
Future Internet, 2019 In order to achieve a multi-path routing algorithm with time delay and energy consumption balance to alleviate the energy holes around a sink, a multimedia independent multipath routing algorithm for internet of things (IoT) based on node hidden ...
Cong Wu, Jianhui Yang
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source