Results 51 to 60 of about 2,220,071 (341)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Migration the Services of Computing Nodes of the AZ-IFAN Grid Site on Scientific Linux 7

Современные информационные технологии и IT-образование, 2019
This article sets the task to consider the most important details of installing and configuring the meta-package worker node (wn), which deploys on the computing node the necessary set of services responsible for performing tasks arriving at the grid ...
Aleksey Bondyakov, Nazim Ali-ogly Huseynov, Jeyhun Akif-ogly Guliyev, Andrey Kondratyev   +3 more
doaj   +1 more source

Transmission Optimization of Social and Physical Sensor Nodes via Collaborative Beamforming in Cyber-Physical-Social Systems [PDF]

Sensors, 2018
The recently emerging cyber-physical-social system (CPSS) can enable efficient interactions between the social world and cyber-physical system (CPS). The wireless sensor network (WSN) with physical and social sensor nodes plays an important role in CPSS.
Bao, Xuecai, Liang, Hao, Han, Longzhe
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Escape into the third dimension in cholesteric liquid crystals

New Journal of Physics
Integer winding disclinations are unstable in a nematic and are removed by an ‘escape into the third dimension’, resulting in a non-singular texture. This process is frustrated in a cholesteric material due to the requirement of maintaining a uniform ...
Joseph Pollard, Gareth P Alexander
doaj   +1 more source

Multi-Frontal Solver For Simulations Of Linear Elasticity Coupled With Acoustics

Computer Science, 2011
This paper describes the concurrent multi-frontal direct solver algorithm for a multi-physicsFinite Element Method (FEM). The multi-physics FEM utilizes different element sizes aswell as polynomial orders of approximation over element edges, faces, and ...
Maciej Paszyński, Tomasz Jurczyk, David Pardo   +2 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Establishing breather and N-soliton solutions for conformable Klein–Gordon equation

Open Physics
This article develops and investigates the behavior of soliton solutions for the spatiotemporal conformable Klein–Gordon equation (CKGE), a well-known mathematical physics model that accounts for spinless pion and de-Broglie waves.
Bilal Muhammad, Iqbal Javed, Ali Rashid, Awwad Fuad A., Ismail Emad A. A.   +4 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Demonstrations of real-time precision optical time synchronization in a true three-node architecture

JPhys Photonics
Multi-node optical clock networks will enable future studies of fundamental physics and enable applications in quantum and classical communications as well as navigation and geodesy.
Kyle W Martin, Nader Zaki, Nolan Matthews, Matthew S Bigelow, Benjamin K Stuhl, John D Elgin, Kimberly Frey   +6 more
doaj   +1 more source