Results 141 to 150 of about 302,372 (340)

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Nitrogen Fixation in Acacias: an Untapped Resource for Sustainable Plantations, Farm Forestry and Land Reclamation [PDF]

Crop Production/Industries,
Brockwell, John, Jeavons, Alison C., Searle, Suzette D., Waayers, Meigan   +3 more
core   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Rarity of monodominance in hyperdiverse Amazonian forests. [PDF]

, 2019
Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence
Alonso, Alfonso, Amaral, Iêda Leão, Andrade, Ana, Araujo-Murakami, Alejandro, Arboleda, Nicolás Castaño, Arroyo, Luzmila, Assis, Rafael L, Aymard C, Gerardo A, Baraloto, Chris, Brienen, Roel, Bánki, Olaf S, Camargo, José Luís, Carim, Marcelo de Jesus Veiga, Carvalho, Fernanda Antunes, Castellanos, Hernán, Castilho, Carolina V, Casula, Katia Regina, Cintra, Bruno Barçante Ladvocat, Coelho, Luiz de Souza, Comiskey, James A, Costa, Flávia RC, Cárdenas López, Dairon, Dallmeier, Francisco, Damasco, Gabriel, de Aguiar, Daniel Praia Portela, de Medeiros, Marcelo Brilhante, de Sousa Farias, Emanuelle, de Souza, Fernanda Coelho, de Toledo, José Julio, Demarchi, Layon O, do Amaral, Dário Dantas, Draper, Freddie, Duivenvoorden, Joost F, Duque, Alvaro, Dávila, Nállarett, Engel, Julien, Feeley, Kenneth J, Feitosa, Yuri Oliveira, Feldpausch, Ted R, Ferreira, Leandro Valle, Filho, Diogenes de Andrade Lima, García-Villacorta, Roosevelt, Gomes, Vitor HF, Groeneveld, Jürgen, Guevara, Juan Ernesto, Guimarães, José Renan da Silva, Helal, Nora, Henkel, Terry W, Honorio Coronado, Euridice N, Huth, Andreas, Irume, Mariana Victória, Killeen, Timothy J, Laurance, Susan GW, Laurance, William F, Lima de Queiroz, Helder, Lloyd, Jon, Lopes, Aline, Lopes, Maria Aparecida, Lozada, José Rafael, Luize, Bruno Garcia, Magalhães, José Leonardo Lima, Magnusson, William E, Manzatto, Angelo Gilberto, Marimon, Beatriz S, Marimon-Junior, Ben Hur, Martins, Maria Pires, Matos, Francisca Dionízia de Almeida, Mendonça Nascimento, Henrique Eduardo, Mendoza, Abel Monteagudo, Mogollón, Hugo F, Molino, Jean-François, Montero, Juan Carlos, Moraes de Leão Novo, Evlyn Márcia, Mostacedo, Bonifacio, Neill, David, Núñez Vargas, Percy, Petronelli, Pascal, Phillips, Oliver L, Piedade, Maria Teresa Fernandez, Pitman, Nigel CA, Quaresma, Adriano, Ramos, José Ferreira, Reis, Neidiane Farias Costa, Revilla, Juan David Cardenas, Rincón, Lorena M, Sabatier, Daniel, Salomão, Rafael P, Schietti, Juliana, Schöngart, Jochen, Silva, Thiago Sanna Freire, Simon, Marcelo Fragomeni, Sousa, Thaiane R, Stevenson, Pablo R, Ter Steege, Hans, Terborgh, John, Vasquez, Rodolfo, Venticinque, Eduardo Martins, Vicentini, Alberto, Vieira, Ima Célia Guimarães, Wittmann, Florian   +99 more
core  

miR‐185‐5p Derived From hUC‐MSC Exosomes via Suspension Culture Under Hypoxic Conditions Promotes Scarless Wound Healing in Mice by Precisely Regulating Collagen I/III Regeneration

Advanced Science, EarlyView.
miR‐185‐5p derived from UC‐MSC exosomes via hypoxic suspension culture promotes scarless wound healing in mice by precisely regulating collagen I/III regeneration. Exosomes derived from UC‐MSCs under a three‐dimensional bioreactor and hypoxic conditions were injected into the skin wounds of mice.
Lihua Yang, Yiqun Sun, Qinbiao Yan, Ali Mohsin, Kamran Ashraf, Senyi Gong, Weifeng Li, Touseef Ur Rehman, Yuwen Hu, Jinzhao He, Yu Liu, Meijun Ding, Lin Qi, Meijin Guo, Ke Xue   +14 more
wiley   +1 more source

Tn-seq profiling reveals that NodS of the beta-rhizobium Paraburkholderia phymatum is detrimental for nodulating soybean

Communications Biology
The beta-rhizobial strain Paraburkholderia phymatum STM815T is noteworthy for its wide host range in nodulating legumes, primarily mimosoids (over 50 different species) but also some papilionoids.
Paula Bellés-Sancho, Daphné Golaz, Sarah Paszti, Alessandra Vitale, Yilei Liu, Aurélien Bailly, Leo Eberl, Euan K. James, Gabriella Pessi   +8 more
doaj   +1 more source

Symbiotic Performance of Diverse Frankia Strains on Salt-Stressed Casuarina glauca and Casuarina equisetifolia Plants [PDF]

, 2016
Symbiotic nitrogen-fixing associations between Casuarina trees and the actinobacteria Frankia are widely used in agroforestry in particular for salinized land reclamation.
Champion, Antony, Diagne, Nathalie, Fardoux, Joel, Gherbi, Hassen, Gray, Krystelle, Hocher, Valerie, Laplaze, Laurent, Ngom, Mariama, Oshone, Rediet, Svistoonoff, Sergio, Sy, Mame Oureye, Tisa, Louis S.   +11 more
core   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Influence of topography and moisture and nutrient availability on green alder function on the low arctic tundra, NT [PDF]

, 2017
The Arctic has warmed by at least 3°C over the past 50 years and this rapid warming is expected to continue. Climate warming is driving the proliferation of shrubs across the tundra biome with implications for energy balance, climate, hydrology, nutrient
Baltzer, Jennifer Lynn, Dr., Black, Katherine Louise, Ms.   +1 more
core   +1 more source