Results 271 to 280 of about 348,085 (390)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Genetic Diversity and Nodulation Potential of <i>Bradyrhizobium</i> Strains in Cowpea and Soybean. [PDF]

Plants (Basel)
Pereira de Moraes Carvalho C, Oliveira AF, Rouws LFM, Dos Santos Dourado F, Reed Rodrigues Coelho M, Alves BJR, Zilli JÉ.   +6 more
europepmc   +1 more source

Sustainable lentil intensification in rice-fallow systems through bioaugmentation with atypical rhizobia and endophytes modulates rhizosphere and nodule microbiome dynamics [PDF]

Sourav Debnath, Silpi Sorongpong, Nandita Das, Kamlesh Choure, Vivek Kumar Agnihotri, Piyush Pandey   +5 more
openalex   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Symbiotic nitrogen fixation for sustainable chickpea yield and prospects for genome editing in changing climatic situations. [PDF]

Front Plant Sci
Mahto RK, B S C, Singh RK, Kumar A, Kumar S, Yadav R, Dey D, Hamwieh A, Kumar R.   +8 more
europepmc   +1 more source

Long-Distance Signaling in Nodulation Directed by a CLAVATA1-Like Receptor Kinase

Science, 2002
I. Searle, A. Men, T. S. Laniya, D. Buzas, I. Iturbe-Ormaetxe, B. Carroll, P. Gresshoff   +6 more
semanticscholar   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Determining the optimal inoculant rate to maximize soybean productivity in the Guinea Savanna agro-ecological zone of Ghana. [PDF]

Sci Rep
Abdul-Aziz AL, Haruna B, Ulzen J, Abukari IA, Haruna A, Abdulai R, Baako AY, Yusif IS.   +7 more
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Nickel treatment of soybean seeds: evaluating optimal levels for <i>Bradyrhizobium</i> spp. survival, nitrogen fixation, physiological traits and grain yield. [PDF]

Front Plant Sci
Moretti LG, Crusciol CAC, Nogueira MA, Bossolani JW, Portugal JR, Hungria M.   +5 more
europepmc   +1 more source