Results 91 to 100 of about 1,238,186 (282)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Statistical analysis based on a two-staged SEM-SVM approach for environmental noise annoyance prediction and identification of influencing factors [PDF]

International Journal of Human Capital in Urban Management
BACKGROUND AND OBJECTIVES: Noise pollution is an environmental stressor that is mainly caused due to heavy transportation in urban scenarios. Traffic noise is a growing concern in urban environments, impacting public health and well-being.
M. Rehman, M. Kamal, S. Tiwari
doaj   +1 more source

Development of mirror coatings for gravitational-wave detectors [PDF]

, 2018
Gravitational waves are detected by measuring length changes between mirrors in the arms of kilometrelong Michelson interferometers. Brownian thermal noise arising from thermal vibrations of the mirrors can limit the sensitivity to distance changes ...
Steinlechner, Jessica
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Insights from the third international conference on hyperacusis: causes, evaluation, diagnosis, and treatment

Noise and Health, 2018
Background: Hyperacusis is intolerance of certain everyday sounds that causes significant distress and impairment in social, occupational, recreational, and other day-to-day activities.
Hashir Aazh, Marlies Knipper, Ali A Danesh, Andrea E Cavanna, Linus Andersson, Johan Paulin, Martin Schecklmann, Marja Heinonen-Guzejev, Brian C.J Moore   +8 more
doaj   +1 more source

Displacement-noise-free gravitational-wave detection with a single Fabry-Perot cavity: a toy model

, 2008
We propose a detuned Fabry-Perot cavity, pumped through both the mirrors, as \textit{a toy model} of the gravitational-wave (GW) detector partially free from displacement noise of the test masses.
Abramovici, Acernese, Ando, Blandford, Blandford, Braginsky, Braginsky, Braginsky, Braginsky, Braginsky, Braginsky, Braginsky, Braginsky, Buonanno, Buonanno, Caves, Caves, Chen, Chen, Danilishin, Danilishin, Flanagan, Ju, Kawamura, Khalili, Khalili, Khalili, Khalili, Khalili, Kimble, Kuroda, Law, Lazebny, Luck, Marzlin, McClelland, Misner, Ni, Rakhmanov, Sato, Schumaker, Sergey P. Tarabrin, Sergey P. Vyatchanin, Sigg, Somiya, Tarabrin, Tarabrin, Unruh, Weinstein   +48 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Effects of static and dynamic higher-order optical modes in balanced homodyne readout for future gravitational waves detectors [PDF]

, 2017
With the recent detection of Gravitational waves (GW), marking the start of the new field of GW astronomy, the push for building more sensitive laser-interferometric gravitational wave detectors (GWD) has never been stronger. Balanced homodyne detection (
Barr, Bryan W., Bell, Angus S., Danilishin, Shtefan L., Dupej, Peter, Gräf, Christian, Hennig, Jan-Simon, Hild, Stefan, Houston, E. Alasdair, Huttner, Sabina H., Leavey, Sean S., Pascucci, Daniela, Sorazu, Borja, Spencer, Andrew, Steinlechner, Sebastian, Strain, Kenneth A., Wright, Jennifer, Zhang, Teng   +16 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optimization of InP APDs for high-speed lightwave systems [PDF]

, 2009
Calculations based on a rigorous analytical model are carried out to optimize the width of the indium phosphide avalanche region in high-speed direct-detection avalanche photodiode-based optical receivers.
David, J.P.R, Hayat, M.M., Ng, J.S., Ong, D.S.G., Sun, P.   +4 more
core   +1 more source