Results 71 to 80 of about 380,497 (248)

Improving Error Estimates for Evaluating Satellite-Based Atmospheric CO₂ Measurement Concepts through Numerical Simulations

Remote Sensing
To assess the accuracy of satellite monitoring of anthropogenic CO2 emissions, inversions of satellite data in SWIR are usually combined with the assimilation of the total CO2 column into a Kalman filter that reconstructs the sources and sinks of ...
Bruna Barbosa Silveira, Vincent Cassé, Olivier Chomette, Cyril Crevoisier   +3 more
doaj   +1 more source

Insights from the third international conference on hyperacusis: causes, evaluation, diagnosis, and treatment

Noise and Health, 2018
Background: Hyperacusis is intolerance of certain everyday sounds that causes significant distress and impairment in social, occupational, recreational, and other day-to-day activities.
Hashir Aazh, Marlies Knipper, Ali A Danesh, Andrea E Cavanna, Linus Andersson, Johan Paulin, Martin Schecklmann, Marja Heinonen-Guzejev, Brian C.J Moore   +8 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Psychoacoustic Evaluation of Shared-Bike Electronic Alert Sounds: Effects of Brand, Sound Pressure Level, and Occurrence Frequency on Annoyance

Applied Sciences
This paper examines the subjective annoyance associated with shared-bike electronic alert sounds (SBeASs), an emerging urban noise source. A study was conducted by employing extensive questionnaire surveys and psychoacoustic experiments.
Kaishi Meng, Linda Liang, Yang Song
doaj   +1 more source

Sensitivity to light and noise [PDF]

Cephalalgia, 1998
Editorial ...
openaire   +1 more source

A revised model of noise sensitivity

Environmental Research: Health
Earlier definitions of noise sensitivity implicitly presupposed that some sounds can objectively be defined as noise and that some people are intrinsically more sensitive to it.
Jiana Wu, Kim N Dirks, Daniel Shepherd, David Welch   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source