Results 31 to 40 of about 45,357 (264)
Mechanisms of Flexible Information Sharing through Noisy Oscillations
Biology, 2021 Brain areas must be able to interact and share information in a time-varying, dynamic manner on a fast timescale. Such flexibility in information sharing has been linked to the synchronization of rhythm phases between areas. One definition of flexibility
Arthur S. Powanwe, Andre Longtin
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Robust AUC optimization under the supervision of clean data
Scientific ReportsAUC (area under the ROC curve) is an essential metric that has been extensively researched in the field of machine learning. Traditional AUC optimization methods need a large-scale clean dataset, while real-world datasets usually contain massive noisy ...
Chenkang Zhang +3 more
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Thinning-free Polygonal Approximation of Thick Digital Curves Using Cellular Envelope
ELCVIA Electronic Letters on Computer Vision and Image Analysis, 2008 Since the inception of successful rasterization of curves and objects in the digital space, several algorithms have been proposed for approximating a given digital curve.
Partha Bhowmick +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Thermal Time Constant CNN-Based Spectrometry for Biomedical Applications
Sensors, 2023 This paper presents a novel method based on a convolutional neural network to recover thermal time constants from a temperature–time curve after thermal excitation.
Maria Strąkowska, Michał Strzelecki
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Delving into Sample Loss Curve to Embrace Noisy and Imbalanced Data [PDF]
, 2021 Shenwang Jiang +5 more
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source