Results 61 to 70 of about 16,499,389 (322)

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Nominative objects in psych verb constructions: formal and experimental approaches

Tollan, RebeccaThis dissertation investigates the nominative object constructions (NOCs) in Korean psych verb constructions, with a focus on their potential to be double nominative arrays (NOM-NOM).
Cho, Juyeon
core   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Color‐Pure Organic Luminophores: Characteristics, Definitions, Physical Basis and Fundamental Design Principles

Angewandte Chemie, EarlyView.
Color‐pure all‐organic emitters, i.e., with narrow spectral characteristics, are intensively studied for high‐definition organic LEDs and multi‐color bioimaging. In order to guide targeted materials design, this educative review discusses spectral characteristics, proper definitions and units, and the physical basis of spectral broadening, to distill ...
Johannes Gierschner, Sunwu Song, Siyang Feng, Liangxuan Wang, Miguel Ródenas, Begoña Milián‐Medina, Min Sang Kwon   +6 more
wiley   +2 more sources

THE FUNDAMENTALS OF WORD-COMPOUND AND COMPOSITE NOMINATION

Гуманитарные и юридические исследования, 2021
The article focuses on the study of the mechanisms that create nomination of wordcombinations and nomination of composites on the material of compound structured formations in flora namings.
O. Ryabko
doaj  

Dėl baltų kalbų nenominatyvinės praeities

Baltistica, 2011
ON THE NON-NOMINATIVE PAST OF THE BALTIC LANGUAGESSummaryThe article enumerates the main works (from 1901 up to 1970) on the non-nominative (ergative) structure of the Indo-European and Baltic parent languages; in the latter the lability of such verbs as
Letas Palmaitis
doaj   +1 more source

English relative clauses in a cross-Germanic perspective

Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2020
The article talk examines the distribution of relativising strategies in English in a cross-Germanic perspective, arguing that English is quite unique among Germanic languages both regarding the number of available options and their distribution.
Julia Bacskai-Atkari
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

The Baix Llobregat (BALL) Demographic Database, between Historical Demography and Computer Vision (nineteenth–twentieth centuries) [Elektronisk resurs] [PDF]

, 2019
The main aims with this book are to compare source materials, databases and research results, as well as creating new opportunities for collaboration in the field of social and population history in the East and the West.
Lladós, Josep,, Fornés, Alicia,, Brea Martinez, Gabriel,, Pujadas-Mora, Joana-Maria,, Valls-Figols, Miquel,, Lund University.   +5 more
core   +2 more sources