An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam +2 more
wiley +1 more source
Conditional survival rates after neoadjuvant chemoradiotherapy combined with surgery in intermediate-low locally advanced rectal cancer based on two-centre retrospective analysis. [PDF]
Wang G, Huang J, Tang H, Huang Y, Guo Y.
europepmc +1 more source
Prognostic nomograms for predicting overall and cancer-specific survival in acute erythroid leukemia: a SEER-based study. [PDF]
Ma X +7 more
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ABSTRACT Purpose The prognostic impact of the interval between the most recent childbirth and breast cancer diagnosis remains insufficiently defined, particularly when breast cancer diagnosed during pregnancy (PrBC) is distinguished from postpartum breast cancer (PPBC).
Liying Wang +5 more
wiley +1 more source
Re: Muhammet Demirbilek, Göktuğ Kalender, Said Bıyıkoglu, et al. External Validation of Nomograms for Predicting Pelvic Lymph Node Metastases in Patients with Prostate Cancer and the Added Value of the Prostate-specific Membrane Antigen Positron Emission Tomography-based PRIMARY Score. Eur Urol Open Sci 2025;82:170-7. [PDF]
Aydin AA, Kayikcioglu E, Yuceer RO.
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ABSTRACT Background Combination immunotherapy is widely used as first‐line treatment for metastatic renal cell carcinoma (mRCC), but pretreatment prognostic stratification remains insufficiently established. Aims To evaluate the performance of various prognostic scores in the first‐line treatment of metastatic renal cell carcinoma (mRCC) with ...
Hiromichi Sakurai +16 more
wiley +1 more source
Venous thromboembolism and bleeding in cancer patients: role of inflammatory and cardiac biomarkers. [PDF]
Roy DC +6 more
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A machine learning model utilizing choroid plexus (CP) radiomics effectively distinguishes Alzheimer's disease (AD) from mild cognitive impairment (MCI) and predicts MCI‐to‐AD progression risk. After integration with clinical features, the model exhibits strong predictive performance. The CP radiomics features correlate significantly with cognitive and
Feiyue Yin +13 more
wiley +1 more source
The prognostic value of the albumin/neutrophil-to-lymphocyte ratio in colorectal cancer patients: a retrospective cohort study. [PDF]
Xie H, Xu N, Wei L, Tang S, Gan J.
europepmc +1 more source
Multi-omics analysis and experimental validation uncovers prognosis significance of IKBIP in patients with hepatocellular carcinoma: a multicenter cohort study. [PDF]
Jiao Y +8 more
europepmc +1 more source

