Results 331 to 340 of about 98,614 (388)

Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 7, Page 1236-1251, July 2025.
ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management of APAP poisoning indicated that management of APAP‐ER
Kyunghee Yang   +8 more
wiley   +1 more source

The Design of Large‐Scale Plasma Donation Trials

open access: yesStatistics in Medicine, Volume 44, Issue 15-17, July 2025.
ABSTRACT Devices for extracting blood from donors require rigorous evaluation for the safety of donors. Complications arise from the fact that outcomes on successive donations from the same donor are not independent, adverse event rates are extremely rare, and there is substantial heterogeneity in the propensity for donors to donate over time.
Kecheng Li, Richard J. Cook
wiley   +1 more source

Roles and Impacts of Integrative Medical Interventions in Central Nervous System Tumor Treatment: Multi‐Technology Convergence and the Paradigm Shift Toward Functional Reconstruction

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Multi‐technology interventions (non‐invasive neuromodulation, AI, 3D organoids) for CNS tumor treatment shift from monotherapy to functional reconstruction. They address BBB restriction, tumor heterogeneity, and immune suppression via biological–psychological–technological convergence, enabling precision oncology through dynamic monitoring and ...
Junda Lai   +5 more
wiley   +1 more source

Computed Tomography Advancements in Plaque Analysis: From Histology to Comprehensive Plaque Burden Assessment

open access: yesEchocardiography, Volume 42, Issue 7, July 2025.
CCTA in coronary disease: from morphological features to advanced imaging biomarkers redefining non‐invasive imaging through comprehensive plaque burden assessment, enabling personalized therapeutic strategies ABSTRACT Advancements in coronary computed tomography angiography (CCTA) facilitated the transition from traditional histological approaches to ...
F. Catapano   +5 more
wiley   +1 more source

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