Results 41 to 50 of about 42,527 (280)

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

Development and validation of a prognostic model for patients with hepatocellular carcinoma undergoing radiofrequency ablation

Cancer Medicine, 2019
Background There are large variations in prognosis among hepatocellular carcinoma (HCC) patients undergoing radiofrequency ablation (RFA). However, current staging or scoring systems hardly discriminate the outcome of HCC patients treated with RFA ...
Chang Gon Kim, Hyun Woong Lee, Hye Jin Choi, Jung Il Lee, Hye Won Lee, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang‐Hyub Han, Han Sang Kim, Kyung Hwan Kim, Seong Jin Choi, Yongun Kim, Kwan Sik Lee, Gyoung Min Kim, Man Deuk Kim, Jong Yoon Won, Do Yun Lee, Beom Kyung Kim   +19 more
doaj   +1 more source

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Leading the Way Towards Greener Business Models in the Wine Industry

Business Strategy and the Environment, EarlyView.
ABSTRACT This study connects ethical leadership and green management to unlock the knowledge behind sustainability success, investigating the impact of environmental management and ethical leadership on the green performance of firms, both directly and indirectly, through the mediating role of green knowledge sharing, providing a framework for ...
Eduardo Sánchez‐García, Javier Martínez‐Falcó, Bartolomé Marco‐Lajara, Laura Abraham   +3 more
wiley   +1 more source

Model‐Informed Precision Dosing of Busulfan for Children and Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Critical Evaluation of Current PK Models and Dose Recommendations

Clinical Pharmacology &Therapeutics, EarlyView.
Busulfan is administered intravenously in conditioning regimens prior to allogeneic hematopoietic stem cell transplantation (HSCT), with model‐informed precision dosing (MIPD) targeting a 4‐day cumulative AUC of 80–100 mg*hour/L. Three pharmacokinetic (PK) models—Bognar, Langenhorst, and McCune—were evaluated using data with a minimum of 1 and a median
Rashudy F. Mahomedradja, Tim Bognàr, Kaj E. van Schie, Ilse T. Kuipers, Moniek A. de Witte, Jurgen H.E. Kuball, Erfan Nur, Bram J. Wilhelm, Marise R. Heerma van Voss, Linda Franken, Arief Lalmohamed, Eleonora (Noortje) L. Swart, Dave C. de Leeuw, Imke H. Bartelink   +13 more
wiley   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Development and Internal Validation of a Nomogram Used to Predict Chemotherapy-Induced Neutropenia in Non-Small Cell Lung Cancer Patients: A Retrospective Cohort Study

Cancer Management and Research, 2021
Wei Zou,1 Neng-Luan Xu2 1Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou ...
Zou W, Xu NL
doaj  

Identification of hub genes for the diagnosis associated with heart failure using multiple cell death patterns

ESC Heart Failure, EarlyView.
Abstract Aims Heart failure (HF) is an important public health problem worldwide, and programmed cell death (PCD) plays a crucial role in its pathologic process. This study aims to identify the hub genes associated with HF through PCD in order to better understand the pathogenesis of HF and improve its diagnosis and treatment.
Hua‐jing Yuan, Hui Yu, Yi‐ding Yu, Xiu‐juan Liu, Wen‐wen Liu, Yi‐tao Xue, Yan Li   +6 more
wiley   +1 more source