Results 51 to 60 of about 17,111,720 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of Scientific Research Achievements in Universities Under the Guidance of "Breaking the Five-Only Criteria": Institutional Representation and Reform Path

Zhishi guanli luntan
[Purpose/Significance] In order to understand the implementation status of scientific research achievements evaluation in Chinese universities under the guidance of "Breaking the Five-Only Criteria", grasp the reform direction of scientific research ...
Yang Siluo, Zhou Zhanyi, Ding Min
doaj   +1 more source

The association between academic performance indicators and lifestyle behaviors among Kuwaiti college students

Journal of Health, Population and Nutrition, 2023
Background Lifestyle behaviors are developed during young adulthood and carried through life. Accordingly, early detection of unhealthy behaviors can help prevent the increase in non-communicable diseases in the population.
Ahmad R. Al-Haifi, Balqees A. Al-Awadhi, Nayef Y. Bumaryoum, Fahhad A. Alajmi, Rasha H. Ashkanani, Hazzaa M. Al-Hazzaa   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Should grades show students\u27 academic achievements or include other non-academic factors?

, 2014
The research question addressed is, should grades show students\u27 academic achievements or include other non-academic factors? It documents one teacher\u27s experience with different grading practices and how that affected her in her academic career ...
Sackett, Samantha C.
core   +1 more source

Academic Achievements: Grades versus Duration [PDF]

, 2015
This paper investigates the determinants of academic achievements of post-reform undergraduate students of Ca’ Foscari University of Venice. Academic achievements are measured with the students’ grade point averages and time to graduation.
CARRARO, Carlo, BRUGIAVINI, Agar, KOVACIC, Matija, .   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Facilities and Infrastructure Management in Improving Student Non-Academic Field Achievement

JIE (Journal of Islamic Education)
This research aims to discuss managing facilities and infrastructure to improve students' non-academic achievements. This research uses a type of field research with a phenomenological approach. Data collection techniques are done through observation, interviews, and documentation. Data reduction, data presentation, and conclusion are the data analysis
Nur Annita Rahmawati, Nurul Latifatul Inayati   +1 more
openaire   +1 more source

Ouachita’s Academic Awards Banquet honors student achievements [PDF]

, 2019
Ouachita Baptist University recently honored students at its 2019 Academic Awards Banquet. The event recognized various academic and leadership achievements by students throughout the 2018-2019 academic year. The annual banquet is sponsored by Ouachita’s
Moreno, Rachel, Ouachita News Bureau,
core