Results 151 to 160 of about 12,550,101 (310)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Appraisal Using Generalized Additive Models [PDF]

open access: yes
Many of the results from real estate empirical studies depend upon using a correct functional form for their validity. Unfortunately, common parametric statistical tools cannot easily control for the possibility of misspecification.
R. Kelley Pace
core  

On regular non-additive measures

open access: yesOn regular non-additive measures
identifier:oai:t2r2.star.titech.ac.jp ...
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Completeness of the σ-additive measure. Measure theory

open access: yes, 1992
Summary. Definitions and basic properties of a σ-additive, non-negative measure, with values in R, the enlarged set of real numbers, where R denotes set R = R ∪ {−∞,+∞}- by [10]. The article includes the text being a continuation of the paper [5].
Józef Białas
core  

Maternal Stressors and Social Support in Early Pregnancy and the Risk of Stillbirth Among Fetuses With Birth Defects: Exploring Effect Modification by Race/Ethnicity. [PDF]

open access: yesBirth Defects Res
Howley MM   +11 more
europepmc   +1 more source

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