Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Cognitive Profiles of Children with Reading Disabilities and/or ADHD. [PDF]
Li M, Kirby JR, Wang T, Zhao W.
europepmc +1 more source
A Quantile Approach to Integration with Respect to Non-additive Measures
Marta Cardin
openalex +2 more sources
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Safety and efficacy of a feed additive consisting of clinoptilolite of volcanic origin for all terrestrial animal species (IMERYS Talc Europe). [PDF]
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +25 more
europepmc +1 more source
New roll-up operator for non-additive numeric measure summarization
Anas Jebreen Atyeeh Husain
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Application of explainable artificial intelligence integrating with electronic health record in oncology. [PDF]
Yang Y, Liu X.
europepmc +1 more source
Regular non-additive measure and Choquet integral
identifier:oai:t2r2.star.titech.ac.jp ...
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source

