Results 81 to 90 of about 18,929,828 (292)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Robust estimation of mean and dispersion functions in extended generalized additive models. [PDF]

Generalized Linear Models are a widely used method to obtain parametric estimates for the mean function. They have been further extended to allow the relationship between the mean function and the covariates to be more flexible via Generalized Additive ...
Croux, Christophe, Prosdocimi, Ilaria, Gijbels, Irène   +2 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

On the hypergraphs associated with integer additive set-labeled graphs [PDF]

, 2015
International audienceLet N 0 denote the set of all non-negative integers and P(N 0) be its power set. An integer additive set-labeling (IASL) of a graph G is an injective set-valued function f : V (G) → P(N 0) such that the induced function f + : E(G) →
Germina, K,, Naduvath, Sudev
core   +1 more source

Explainable machine learning identifies knee morphology thresholds for arthroscopic medial meniscus posterior root tear: a retrospective cohort study

Frontiers in Medicine
BackgroundMedial meniscus posterior root tear (MMPRT) is clinically important because disruption of posterior root function compromises hoop tension and load sharing, accelerating medial-compartment degeneration.
Minyuan Zhang, Fengyuan Guo, Yanlin Li, Jiali Zheng, Yang Yu, Miao Chen, Runze Li, Yatong Liao, Qianzeng Chen, Chuan He   +9 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Dynamic Surface Control for Nonlinear Bilateral Teleoperation Manipulators with Guaranteed Transient Performance

Tsinghua Science and Technology
In this article, a finite-time adaptive dynamic surface synchronization tracking controller with guaranteed transient performance is proposed for bilateral teleoperation manipulators.
Hang Li, Wusheng Chou
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Oracally Efficient Two-Step Estimation of Generalized Additive Model [PDF]

Generalized additive models (GAM) are multivariate nonparametric regressions for non-Gaussian responses including binary and count data. We propose a spline-backfitted kernel (SBK) estimator for the component functions.
Wolfgang Karl Härdle, Rong Liu, Lijian Yang   +2 more
core