Results 161 to 170 of about 16,858,371 (288)

Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer. [PDF]

Cancer Res
Clarke MA, Barker CG, Nicholls A, Handler MP, Pickard L, Shah AZ, Walter D, De Braekeleer E, Banerji U, Choudhary JS, Ahmad SS, McDermott U, Hannon GJ, Fisher J.   +13 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Interpretable self-driving sputtering epitaxy reveals human-usable growth rules for β-Ga₂O₃ films. [PDF]

Nat Commun
Wakabayashi YK, Ogawa Y, Romero FB, Wagner C, Otsuka T, Taniyasu Y.   +5 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Non-additive Ring and Module theory [PDF]

, 1977
Pareigis, Bodo
core   +1 more source

An Algorithm for Clustered Data Generalized Additive Modelling with S-PLUS [PDF]

We present a set of functions in S-PLUS to implement the clustered data generalized additive marginal modelling (CDGAM) strategy proposed by Berhane and Tibshirani (1998).
Vincent Carey, Lin Yee Hin
core  

An Interpretable Machine Learning Approach to Ecologically Characterize Soil Carbon and Structure From Multi-Kingdom Microbiome, Texture and Climate. [PDF]

Mol Ecol
Jeanne T, Prunier J, Hogue R, Droit A.
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Integrating multi-layer perceptron and random forest in an ensemble framework for improved genomic prediction accuracy and SHAP-derived interpretability of residual feed intake in cattle. [PDF]

J Anim Sci Biotechnol
Ong EJK, Mooney MH, Rezwan FI, Wang H, Shirali M.   +4 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source