Results 81 to 90 of about 558,700 (260)

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

Clinical Epigenetics, 2019
Background Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me).
Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz, Steven A. Johnsen   +15 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Product Space Models of Correlation: Between Noise Stability and Additive Combinatorics

Discrete Analysis, 2018
Product Space Models of Correlation: Between Noise Stability and Additive Combinatorics, Discrete Analysis 2018:20, 63 pp. Szemerédi's theorem states that for every positive integer $\ell$ and every $\mu>0$ there exists $N$ such that every subset of ...
Jan Hązła, Thomas Holenstein, Elchanan Mossel   +2 more
doaj   +1 more source

Error Modelling for Multi-Sensor Measurements in Infrastructure-Free Indoor Navigation

Sensors, 2018
The long-term objective of our research is to develop a method for infrastructure-free simultaneous localization and mapping (SLAM) and context recognition for tactical situational awareness.
Laura Ruotsalainen, Martti Kirkko-Jaakkola, Jesperi Rantanen, Maija Mäkelä   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Assessing the Alteration of Soil Quality under Long-Term Fertilization Management in Farmland Soil: Integrating a Minimum Data Set and Developing New Biological Indicators

Agronomy
The key role of soil quality improvement in achieving sustainable agricultural development based on highly intensive use of farmland is increasingly being recognized, as is the ponderance of suitable evaluation of the soil quality.
Peng Li, Yue Zhang, Chengzhe Li, Zihan Chen, Duo Ying, Shanyi Tian, Gen Zhao, Dongmei Ye, Chihang Cheng, Choufei Wu, Liqin Zhang, Jiaguo Jiao, Feng Hu   +12 more
doaj   +1 more source

The quest for targets executing MYC-dependent cell transformation

Frontiers in Oncology, 2016
MYC represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding RNAs important for cell proliferation,
Markus eHartl
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Additive contributions of melanopsin and both cone types provide broadband sensitivity to mouse pupil control

BMC Biology, 2018
Background Intrinsically photosensitive retinal ganglion cells (ipRGCs) drive an array of non-image-forming (NIF) visual responses including circadian photoentrainment and the pupil light reflex.
Edward A. Hayter, Timothy M. Brown
doaj   +1 more source