Results 61 to 70 of about 8,104,442 (314)
Parametric alignment of Drosophila genomes. [PDF]
PLoS Computational Biology, 2006 The classic algorithms of Needleman-Wunsch and Smith-Waterman find a maximum a posteriori probability alignment for a pair hidden Markov model (PHMM). To process large genomes that have undergone complex genome rearrangements, almost all existing whole ...
Colin N Dewey +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Non-Parametric 3D Shape Warping
, 2010 A method is presented for non-rigid alignment of a source shape to a target shape through estimating and interpolating point-wise correspondences between their surfaces given as point clouds.
U. Hillenbrand, U., Ulrich Hillenbrand
core +1 more source
Acta Academiae Artium VilnensisThis paper examines the discursive recuperation of “non-aligned” histories and non-alignment—understood as the set of ideas and values behind the Non-Aligned Movement established in the 1960s1—in the interpretation of two African collections, the Museum ...
Ana Sladojević
doaj +1 more source
Identifying and seeing beyond multiple sequence alignment errors using intra-molecular protein covariation. [PDF]
PLoS ONE, 2010 BACKGROUND: There is currently no way to verify the quality of a multiple sequence alignment that is independent of the assumptions used to build it. Sequence alignments are typically evaluated by a number of established criteria: sequence conservation ...
Russell J Dickson +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Tracking relevant alignment characteristics for machine translation [PDF]
, 2009 In most statistical machine translation (SMT) systems, bilingual segments are extracted via word alignment. In this paper we compare alignments tuned directly according to alignment F-score and BLEU score in order to investigate the alignment ...
Sylwia Ozdowska +7 more
core