Results 41 to 50 of about 344,689 (283)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

“The Pronouns EXIST!”: Linguistic Existence in the Borderlands as a U.S. Non-Binary Adolescent Heritage Learner of Spanish

Critical Multilingualism Studies
Debates about teaching inclusive Spanish are frequently simplified into a false binary, in which linguistic evolutions advocated by trans and queer communities are framed as opposite to the linguistic conservativism of Spanish-speaking communities in the
Julia Donnelly Spiegelman
doaj   +2 more sources

Non-binary experiences of language: the effect of neologisms in the search for affirming self-description [PDF]

, 2023
This thesis studies the effects of explanatory gaps in language and neologisms on non-binary individuals seeking affirming self-description. It explores trends within non-binary communities towards the use of neologisms and potential obstacles to wider ...
Furniss-Greasley, Rai
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Metathesis and unmetathesis in Amarasi

, 2020
This book provides a complete analysis of synchronic CV -> VC metathesis in Amarasi, a language of western Timor. Metathesis and unmetathesis realise a paradigm of parallel forms, pairs of which occur to complement each other throughout the language ...
Edwards, Owen; Leiden University and Language & Culture Unit (UBB), Kupang
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Creating a Gender-inclusive Learning Environment in Spanish Language Classrooms

Canadian Journal for the Scholarship of Teaching and Learning
Non-binary speakers often struggle to describe themselves within the binary gender system of Spanish. This is even more of a challenge for learners of Spanish who are used to describing themselves in English without having to identify their gender.
Diana Carter, Angela George, Francis Langevin   +2 more
doaj   +1 more source

Trans and Non-Binary Experiences of Maternity Services

, 2022
The Improving Trans Experiences of Maternity Services (ITEMS) project is a collaborative research project commissioned by the Health & Wellbeing Alliance, which is jointly managed by the Department of Health and Social Care (DHSC), Public Health ...
Martin, Paul, Pearce, Ruth, Topper, Yuval, LGBT Foundation   +3 more
core  

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source