Results 171 to 180 of about 894,957 (355)

Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus

Cellular & Molecular Biology Letters
Background Extrachromosomal circular DNAs (eccDNAs) exist in human blood and somatic cells, and are essential for oncogene plasticity and drug resistance. However, the presence and impact of eccDNAs in type 2 diabetes mellitus (T2DM) remains inadequately
Xiang Kong, Shu-jun Wan, Tian-bing Chen, Lan Jiang, Yu-jie Xing, Ya-ping Bai, Qiang Hua, Xin-ming Yao, Yong-li Zhao, Hong-mei Zhang, De-guo Wang, Qing Su, Kun Lv   +12 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation

Frontiers in Immunology
β-Hydroxybutyrylation (Kbhb) is a novel posttranslational modification (PTM) mediated by β-hydroxybutyrate (BHB). BHB, the core product of ketogenic metabolism, serves as its direct precursor and substrate.
Fangshuai Hu, Fangshuai Hu, Changming Liang, Changming Liang, Xu Zhang, Xu Zhang, Lishuai Xu, Lishuai Xu, Chengwei Wu, Chengwei Wu, Senlin Wan, Senlin Wan, Jiawei Wang, Jiawei Wang, Mengyun Wang, Mengyun Wang, Dawei Zhang, Dawei Zhang, Yongchun Liu, Yongchun Liu, Zhenyuan Li, Zhenyuan Li, Xiaoming Wang, Xiaoming Wang, Xiaoxu Huang, Li Xu, Li Xu, Li Xu   +27 more
doaj   +1 more source

Computational mechanisms in genetic regulation by RNA

, 2018
The evolution of the genome has led to very sophisticated and complex regulation. Because of the abundance of non-coding RNA (ncRNA) in the cell, different species will promiscuously associate with each other, suggesting collective dynamics similar to ...
Deutsch, J. M.
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Glutathiones’ life in multi-cancers: especially their potential micropetides in liver hepatocellular carcinoma

Discover Oncology
Background Glutathione plays critical roles in detoxifying xenobiotics, cell signaling, cell death and the antioxidant defence in an emerging body of evidence, the most abundant intracellular low molecular weight thiol in tissues.
Didi Ma, Zhenguo Wu, Mengying Zhang, Jian Mao, Wenqin Xu, Lan Jiang, Zuzhen Wang   +6 more
doaj   +1 more source

Additional file 11: of Identification of functional long non-coding RNAs in C. elegans

, 2019
Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesiński, Chris P. Ponting, Eric A. Miska, Wilfried Haerty   +6 more
openalex   +1 more source

c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer [PDF]

, 2019
Linlei Zhang, Yanying Fu, Hao Guo
openalex   +1 more source

Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature

, 2021
Ya Guo, Peng Yang, Zhong Wei Wang, Kun Xu, Wei Kou, Heng Luo   +5 more
openalex   +1 more source