Results 101 to 110 of about 1,704,490 (380)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Associations of changes in waist circumference and BMI with variation of fasting blood glucose among middle aged and elderly residents at high cardiovascular risk: a follow-up study in Jiangsu province

Zhongguo gonggong weisheng
Objective To investigate associations of changes in waist circumference (WC) and body mass index (BMI) with the variation of fasting blood glucose among middle aged and elderly residents with high cardiovascular risk.
Xun WU, Yu QIN, Jian SU, Lulu CHEN, Lan CUI, Ran TAO, Jinyi ZHOU   +6 more
doaj   +1 more source

Identifikasi Indikator dalam Indeks Pembangunan Kesehatan Masyarakat (IPKM) untuk Meningkatkan Nilai Sub-Indeks Penyakit Menular [PDF]

, 2017
Since 2009, Ministry of Health through Indonesia Agency fro Health Research and Development has formulated Public Health Dvelopment Index (PHDI) to describe public health status in Indonesia.
Dharmayanti, I. (Ika), Tjandararini, D. H. (Dwi)   +1 more
core  

Urbanization and non-communicable disease mortality in Thailand: an ecological correlation study.

, 2013
This study provides strong evidence from an LMIC that urbanization is associated with mortality from three lifestyle-associated diseases at an ecological level.
Allender, Allender, Archavanitkul, Banwell, Bentham, Boutayeb, Cochrane, Cohen, Faramnuayphol, Flood, Harpham, Hernandez, Holt-Lunstad, Kosulwat, Leon, Lim, Maheswaran, Mathers, Odton, Pattaraarchachai, Petcharoen, Phillips, Porapakkham, Pritchard, Rao, Schorr, Sethapongkul, Sleigh, Smith, Srimahachota, Tangcharoensatien, Vapattanawong, Venketasubramanian, Viravaidya, Vlahov, World Health Organization, Yang, Yiengprungsawan, Yiengprungsawan, Young   +39 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

First Africa non-communicable disease research conference 2017: sharing evidence and identifying research priorities

Journal of Global Health, 2019
Non-communicable diseases (NCDs) prevalence is rising fastest in lower income settings, and with more devastating outcomes compared to High Income Countries (HICs).
Kenneth Juma, Pamela A. Juma, S. Mohamed, J. Owuor, Agnes N Wanyoike, David Mulabi, George Odinya, Maureen Njeru, G. Yonga   +8 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults

Scientific Reports
Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms.
Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu   +6 more
doaj   +1 more source

The UK's Global Health Respiratory Network: Improving respiratory health of the world's poorest through research collaborations. [PDF]

, 2019
Respiratory disorders are responsible for considerable morbidity, health care utilisation, societal costs and approximately one in five deaths worldwide [1-4].
Adab, P, Balharry, D, Barreto, ML, Bauld, L, Campbell, H, Cooper, P, Cruz, A, Davidson, FM, Dodd, P, Enocson, A, Fitch, N, Griffiths, C, Grigg, J, Heyderman, RS, Jordan, R, Katikireddi, SV, Kuo, S, Kwambana-Adams, B, Leyland, AH, Mortimer, K, Mosler, G, Obasi, A, Orme, M, Readshaw, A, Savio, M, Sheikh, A, Siddiqi, K, Sifaki-Pistolla, D, Singh, S, Squire, B, Tsiligianni, I, Williams, S   +31 more
core   +9 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source