Results 81 to 90 of about 1,219,864 (340)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

Sports Medicine and Health Science, 2022
To understand the association between cardiometabolic risk factor (CMRF) clustering and physical activity (PA) levels, we included 86520 Chinese adults aged 18–64 years having at least one CMRF (hypertension, diabetes, dyslipidemia, or obesity) from the ...
Xiaorong Chen, Mei Zhang, Limin Wang, Zhengjing Huang, Wenrong Zhang, Jing Wu   +5 more
doaj  

Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17).

The Lancet Diabetes and Endocrinology, 2023
R. Anjana, R. Unnikrishnan, M. Deepa, R. Pradeepa, N. Tandon, A. Das, Shashank R. Joshi, S. Bajaj, P. K. Jabbar, H. Das, Ajay Kumar, V. Dhandhania, A. Bhansali, P. Rao, Ankush K Desai, S. Kalra, Arvind Gupta, R. Lakshmy, S. Madhu, Nirmal Elangovan, S. Chowdhury, U. Venkatesan, R. Subashini, T. Kaur, R. Dhaliwal, V. Mohan   +25 more
semanticscholar   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]

arXiv, 2017
The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The development of nations conditions the disease space [PDF]

arXiv, 2019
Using the economic complexity methodology on data for disease prevalence in 195 countries during the period of 1990-2016, we propose two new metrics for quantifying the relatedness between diseases, or the `disease space' of countries. With these metrics, we analyze the geography of diseases and empirically investigate the effect of economic ...
arxiv  

Pattern, correlates and implications of non-communicable disease multimorbidity among older adults in selected Indian states: a cross-sectional study

BMJ Open, 2017
Objectives The objective of the present study was to estimate the proportion of older adults with non-communicable disease (NCD) multimorbidity, its correlates and implications in selected Indian states. Methods The study used data of 9852 older adults (≥
G. K. Mini, K. Thankappan
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Analysis of core information awareness of chronic disease prevention and control and its influencing factors among adult residents in Heilongjiang province in 2021: an online survy

Zhongguo gonggong weisheng
ObjectiveTo understand the core information awareness of chronic disease prevention and control and its influencing factors among adult residents in Heilongjiang province, and to provide a reference for formulating chronic disease prevention and control ...
Yong ZHOU, Lei WANG, Lin JIN, Jiancheng ZHAO, Yangchun LI, Xiaoming CUI, Wei SUN, Shichun YAN   +7 more
doaj   +1 more source