Results 41 to 50 of about 746,464 (231)

The influence of heterogenous porosity on silicon nitride/steel wear in lubricated rolling contact [PDF]

, 2000
Heterogeneous porosity is detected on the surface and subsurface of hot isostatically pressed (HIPed) silicon nitride spherical rolling elements. The extent of the localised porosity accounts for an area of 6% of the rolling element surface and 4% of the
Hadfield, M, Kang, J
core  

Electromagnetic and mechanical characterisation of ITER CS-MC conductors affected by transverse cyclic loading, part 1: coupling current loss [PDF]

, 1999
The magnetic field generated by a coil acts on the cable which results in a transverse force on the strands. This affects the interstrand contact resistances (Rc), the coupling current loss and current redistribution during field changes.
Bruzzone, Pierluigi, Kate, Herman H.J. ten, Mitchell, Neil, Nijhuis, Arend, Noordman, Niels H.W.   +4 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

An impedance approach to reduce the contact-instability whilst drilling with active heave compensation [PDF]

, 2012
The bit-bounce, or contact-instability, phenomenon which occurs in the drill string suspended from a floating vessel with an active drill string compensator to maintain a steady weight on the drill bit is investigated.
Dunnigan, Mathew Walter, Hatleskog, Jan
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Trends in Lubrication Research on Tapered Roller Bearings: A Review by Bearing Type and Size, Lubricant, and Study Approach

Lubricants
A tapered roller bearing (TRB) is a specialized type of bearing with a high load-to-volume ratio, designed to support both radial and axial loads. Lubrication plays a crucial role in TRB operation by reducing friction and dissipating heat generated ...
Muhammad Ishaq Khan, Lorenzo Maccioni, Franco Concli   +2 more
doaj   +1 more source

Fire analysis of steel-concrete composite beam with interlayer slip [PDF]

, 2011
The paper discusses the effects of slip and moisture transfer on the behaviour of a planar steel-concrete composite beam subject to fire conditions.
Hozjan, Tomaž, Planinc, Igor, Saje, Miran, Srpčič, Stanislav   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source