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Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham   +11 more
wiley   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

open access: yesAdvanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij   +8 more
wiley   +1 more source
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Non-covalent interactions in biomacromolecules

Physical Chemistry Chemical Physics, 2007
Non-covalent interactions play an important role in chemistry, physics and especially in biodisciplines. They determine the structure of biomacromolecules such as DNA and proteins and are responsible for the molecular recognition process. Theoretical evaluation of interaction energies is difficult; however, perturbation as well as variation ...
Jirí, Cerný, Pavel, Hobza
openaire   +2 more sources

Studying non-covalent drug–DNA interactions

Archives of Biochemistry and Biophysics, 2015
Drug-DNA interactions have been extensively studied in the recent past. Various techniques have been employed to decipher these interactions. DNA is a major target for a wide range of drugs that may specifically or non-specifically interact with DNA and affect its functions.
Sayeed Ur, Rehman   +4 more
openaire   +2 more sources

Non-covalent interactions in clathrate complexes

Journal of Coordination Chemistry, 2021
Intermolecular interactions in clathrates are compared to those in supramolecular complexes in solution, with an emphasis on van der Waals, or dispersive contributions.
Janusz Lipkowski, Hans-Jörg Schneider
openaire   +1 more source

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