Results 191 to 200 of about 15,166 (238)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

From Launch to Legacy: Charting the Path of the Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution. [PDF]

open access: yesEnviron Sci Technol
Pavoncello V   +6 more
europepmc   +1 more source

Toward ethical provenance tracking: The GA4GH model data access agreement (DAA). [PDF]

open access: yesGenet Med
Bernier A   +5 more
europepmc   +1 more source

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