Results 41 to 50 of about 147,787 (297)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Probing Krylov complexity in scalar field theory with general temperatures

Journal of High Energy Physics
Krylov complexity characterizes the operator growth in the quantum many-body systems or quantum field theories. The existing literatures have studied the Krylov complexity in the low temperature limit in the quantum field theories.
Peng-Zhang He, Hai-Qing Zhang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Thermal field theory in non-equilibrium states [PDF]

, 1995
Conventional transport theory is not really applicable to non-equilibrium systems which exhibit strong quantum effects. We present two different approaches to overcome this problem.
Nakamura, K. (Meiji Univ., Tokyo (Japan). Div. of Natural Sciences), Henning, P.A. (Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany). Inst. fuer Theoretische Physik), Yamanaka, Y. (Waseda Univ., Tokyo (Japan)), Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)   +3 more
core  

Facets of Non-Equilibrium in Perturbative Quantum Field Theory : an Algebraic Approach [PDF]

, 2018
In this thesis we study some non-equilibrium aspects of an interacting, massive scalar field theory treated perturbatively. This is done analysing some properties of the interacting KMS state constructed by Fredenhagen and Lindner [FL14] in the framework
FALDINO, FEDERICO MARIA
core   +1 more source

Hydrodynamics as v s → c

Journal of High Energy Physics
I present the simplest 3+1 dimensional quantum field theory for which the speed of sound can be arbitrarily close to the speed of light. Examining the hydrodynamics, I find cases where the shear viscosity is finite, but the “shear relaxation coefficient”
Guy D. Moore
doaj   +1 more source

Perturbative nonequilibrium thermal field theory [PDF]

Physical Review D, 2013
We present a new perturbative formulation of non-equilibrium thermal field theory, based upon non-homogeneous free propagators and time-dependent vertices. Our approach to non-equilibrium dynamics yields time-dependent diagrammatic perturbation series that are free of pinch singularities, without the need to resort to quasi-particle approximation or ...
Millington, P; id_orcid 0000-0001-6942-8257, Pilaftsis, A; id_orcid 0000-0001-6217-2711   +1 more
openaire   +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Large distance expansion in the Schrödinger representation of quantum field theory [PDF]

, 1997
This thesis is concerned with an approach to Quantum Field Theory in which the states are constructed from their large distance behaviour. The logarithm of the vacuum functional is expandable as a local quantity in any quantum field theory in which the ...
Sampaio, Marcos Donizeti Rodrigues, Rodrigues Sampaio, M.D.   +1 more
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