Results 111 to 120 of about 10,118,746 (283)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Design and performance test of four elements combined exhaust aftertreatment system for mine explosion-proof diesel engine

Meitan xuebao
Explosion-proof diesel engine is one of the most widely used power sources for auxiliary transportation vehicles in coal mines at present. It is affected by explosion-proof transformation and harsh underground environment, resulting in serious exhaust ...
Lei ZHANG, Binzhan TANG, Jiusheng BAO, Zhiwei HU, Zhen PENG, Deping HU, Yan YIN, Xiaoming YUAN   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Total Suspended Particulate Matter (TSP)-Bound Carbonaceous Components in a Roadside Area in Eastern Indonesia

Urban Science
To evaluate carbonaceous components in the ambient air in the eastern region of Indonesia, 35 Total Suspended Particulate Matter (TSP) samples were collected on four characteristic roadsides on Sultan Alauddin Street, in Makassar City, using a high ...
Muhammad Amin, Andi Annisa Tenri Ramadhani, Rasdiana Zakaria, Zarah Arwieny Hanami, Rahmi Mulia Putri, Worradorn Phairuang, Mitsuhiko Hata, Masami Furuuchi   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Differentiated impact of low-exhaust-emission vehicles on NO $$_\text {2}$$ 2 and particle concentrations in the Paris region

European Transport Research Review
Higher concentrations of air pollutants, such as nitrogen dioxide (NO $$_\text {2}$$ 2 ) and particulate matter (PM), are observed in streets compared to the urban background.
Thibaud Sarica, Christophe Chaillou, Yelva Roustan, Clément Larrieu, Salah-Eddine Wali, Karine Sartelet   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Development Of Monolithic Catalysts For Storage And Reduction Of Nitrogen Oxide (Nox) In Diesel Engine Exhaust. [PDF]

, 2008
Pembangunan mangkin monolit bagi penstoran dan seterusnya penurunan NOx dalam gas ekzos injin diesel telah dikaji. Zeolit ZSM-5 telah digunakan sebagai sokongan berluas permukaan tinggi untuk disalut ke atas monolit seramik.
Bhatia, Subhash, Abdullah, Ahmad Zuhairi
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source