Results 1 to 10 of about 17,654 (241)

New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process. [PDF]

PLoS One, 2016
In dilated cardiomyopathy (DCM), cardiac failure is accompanied by profound alterations of extracellular matrix associated with the progression of cardiac dilation and left ventricular (LV) dysfunction. Recently, we reported alterations of non-fibrillar collagen expression in ischemic cardiomyopathy linked to fibrosis and cardiac remodeling. We suspect
Gil-Cayuela C, Roselló-LLetí E, Ortega A, Tarazón E, Triviño JC, Martínez-Dolz L, González-Juanatey JR, Lago F, Portolés M, Rivera M.   +9 more
europepmc   +8 more sources

Novel Fibrillar and Non-Fibrillar Collagens Involved in Fibrotic Scar Formation after Myocardial Infarction [PDF]

Int J Mol Sci
Following myocardial infarction (MI), adverse remodeling depends on the proper formation of fibrotic scars, composed of type I and III collagen. Our objective was to pinpoint the participation of previously unreported collagens in post-infarction cardiac fibrosis.
Ortega M, Fábrega-García M, Molina-García T, Gavara J, de Dios E, Pérez-Solé N, Marcos-Garcés V, Padilla-Esquivel J, Diaz A, Martinez-Dolz L, Jimenez-Navarro M, Rios-Navarro C, Bodí V, Ruiz-Saurí A.   +13 more
europepmc   +7 more sources

A block staining method using ethanolic phosphotungstic acid for the visualisation of collagens in transmission electron microscopy. [PDF]

PLoS One
Conventional transmission electron microscopic imaging of biological samples requires contrast enhancement by staining with heavy metal salts. The most widely used stains are uranyl acetate and its non-radioactive lanthanoid replacements, and lead ...
Obermayer A, Hainzl S, Koller U, Lang D, Lamprecht B, Stoiber W.   +5 more
europepmc   +2 more sources

Single-Cell Transcriptomic Landscape of Cervical Cancer Cell Lines Before and After Chemoradiotherapy. [PDF]

Cells
Cervical cancer remains a significant global health burden, with chemoradioresistance representing a major obstacle to successful treatment. To elucidate the mechanisms underlying this resistance, we established a unique pair of isogenic primary cervical
Semenov DV, Tatarnikova IS, Chesnokova AS, Talyshev VA, Zenkova MA, Logashenko EB.   +5 more
europepmc   +2 more sources

Non-fibrillar collagenous proteins synthesized by rat mesangial cells. [PDF]

Journal of the American Society of Nephrology, 1990
Recent studies have shown that nonrenal extracellular matrices are composed of collagenous proteins with properties that are different from those of fibrillar collagens and type IV collagen. The structures of these newly described collagens suggest that they may provide connections between specific matrix molecules and, in so doing, partially determine
N D, Rosenblum, M J, Karnovsky, B R, Olsen   +2 more
openaire   +2 more sources

Quantification and Comparison of Anti-Fibrotic Therapies by Polarized SRM and SHG-Based Morphometry in Rat UUO Model. [PDF]

PLoS ONE, 2016
Renal interstitial fibrosis (IF) is an important pathologic manifestation of disease progression in a variety of chronic kidney diseases (CKD). However, the quantitative and reproducible analysis of IF remains a challenge, especially in experimental ...
Hu Sheng Qian, Steve M Weldon, Damian Matera, ChungWein Lee, Haichun Yang, Ryan M Fryer, Agnes B Fogo, Glenn A Reinhart   +7 more
doaj   +1 more source

Modulation of Cardiac Fibrosis in and Beyond Cells

Frontiers in Molecular Biosciences, 2021
The extracellular matrix (ECM) plays important roles in maintaining physiological structure and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of ECM, including both fibrillar (collagens I and III) and non-fibrillar ...
Dong Fan, Zamaneh Kassiri
doaj   +1 more source

Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis

Frontiers in Oncology, 2020
Cancers are complex ecosystems composed of malignant cells embedded in an intricate microenvironment made of different non-transformed cell types and extracellular matrix (ECM) components.
Isabelle Bourgot, Irina Primac, Thomas Louis, Agnès Noël, Erik Maquoi   +4 more
doaj   +1 more source

Fibrillar Collagen Type I Participates in the Survival and Aggregation of Primary Hepatocytes Cultured on Soft Hydrogels

Biomimetics, 2020
Liver is an essential organ that carries out multiple functions such as glycogen storage, the synthesis of plasma proteins, and the detoxification of xenobiotics.
Nathalia Serna-Márquez, Adriana Rodríguez-Hernández, Marisol Ayala-Reyes, Lorena Omega Martínez-Hernández, Miguel Ángel Peña-Rico, Jorge Carretero-Ortega, Mathieu Hautefeuille, Genaro Vázquez-Victorio   +7 more
doaj   +1 more source

Central fibrous area in the glomerular vascular pole consists of fibrous collagens and is associated with advanced age: a cross-sectional study

BMC Nephrology, 2022
Background For the optimal management of patients with both allograft kidneys and native kidney diseases, the recognition of the histological features associated with older age is important.
Satoshi Hara, Yutaka Yamaguchi, Takeshi Zoshima, Ichiro Mizushima, Kazunori Yamada, Ryo Inoue, Hisao Muto, Kazuaki Mizutomi, Masayoshi Hirata, Hideo Araki, Ryoichi Miyazaki, Mitsuhiro Kawano   +11 more
doaj   +1 more source