Results 11 to 20 of about 17,654 (241)

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study. [PDF]

PLoS ONE, 2016
BACKGROUND AND AIMS:Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD).
Juho Pirhonen, Johanna Arola, Sanja Sädevirta, Panu Luukkonen, Sanna-Maria Karppinen, Taina Pihlajaniemi, Antti Isomäki, Mika Hukkanen, Hannele Yki-Järvinen, Elina Ikonen   +9 more
doaj   +1 more source

Mechanical and Structural Contribution of Non-Fibrillar Matrix in Uniaxial Tension: A Collagen-Agarose Co-Gel Model [PDF]

Annals of Biomedical Engineering, 2011
The mechanical role of non-fibrillar matrix and the nature of its interaction with the collagen network in soft tissues remain poorly understood, in part because of the lack of a simple experimental model system to quantify these interactions. This study's objective was to examine mechanical and structural properties of collagen-agarose co-gels ...
Spencer P, Lake, Victor H, Barocas
openaire   +2 more sources

The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation

Frontiers in Cell and Developmental Biology, 2022
Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs; however, the relative contribution of these two ...
Corina M. Borza, Gema Bolas, Xiuqi Zhang, Mary Beth Browning Monroe, Ming-Zhi Zhang, Jens Meiler, Jens Meiler, Marcin J. Skwark, Raymond C. Harris, Lynne A. Lapierre, Lynne A. Lapierre, James R. Goldenring, James R. Goldenring, James R. Goldenring, Magnus Hook, Jose Rivera, Kyle L. Brown, Birgit Leitinger, Matthew J. Tyska, Markus Moser, Ralph T. Böttcher, Roy Zent, Roy Zent, Roy Zent, Ambra Pozzi, Ambra Pozzi   +25 more
doaj   +1 more source

Mechanics of a Fiber Network Within a Non-Fibrillar Matrix: Model and Comparison with Collagen-Agarose Co-gels [PDF]

Annals of Biomedical Engineering, 2012
While collagen is recognized as the predominant mechanical component of soft connective tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model systems, such as the collagen-agarose co-gel, can exhibit complex behavior, making it difficult to identify relative contributions of specific tissue constituents. In the present
Spencer P, Lake, Mohammad F, Hadi, Victor K, Lai, Victor H, Barocas   +3 more
openaire   +2 more sources

The use of urinary proteomics in the assessment of suitability of mouse models for ageing [PDF]

, 2017
Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can ...
Bajwa, Seerat, Bascands, Jean-Loup, Bechtel-Walz, Wibke, Borries, Melanie, Busch, Hauke, Dray, Cédric, Huber, Tobias B., Koeck, Thomas, Mischak, Harald, Nkuipou-Kenfack, Esthet, Pejchinovski, Martin, Pich, Andreas, Rudolph, Karl L., Schanstra, Joost P., Valet, Philippe, Vinel, Claire, Vlahou, Antonia, Zürbig, Petra   +17 more
core   +7 more sources

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis

Journal of Cardiovascular Development and Disease, 2019
The extracellular matrix (ECM) provides structural support and a microenvironmentfor soluble extracellular molecules. ECM is comprised of numerous proteins which can be broadly classified as fibrillar (collagen types I and III) and non-fibrillar ...
Michael Chute, Preetinder Aujla, Sayantan Jana, Zamaneh Kassiri   +3 more
doaj   +1 more source

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +3 more sources

Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells. [PDF]

PLoS ONE, 2013
Uterine leiomyomas (ULs) are benign tumors occurring in the majority of reproductive aged women. Despite the high prevalence of these tumors, little is known about their etiology. A hallmark of ULs is the excessive deposition of extracellular matrix (ECM)
Faezeh Koohestani, Andrea G Braundmeier, Arash Mahdian, Jane Seo, JiaJia Bi, Romana A Nowak   +5 more
doaj   +1 more source

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. [PDF]

, 2016
OBJECTIVE: To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-
Arciniegas, Beon, Cooley, Del Galdo, Falke, Gabrielli, Gilbane, Good, Goumans, Hashimoto, Herzog, Herzog, Hinz, Hinz, Humphreys, Jimenez, Katsumoto, Kendall, Kramann, Lamouille, LeBleu, Li, Li, Marelli-Berg, Matucci-Cerinic, McAnulty, Medici, Meeteren, Nolan, Pattanaik, Piera-Velazquez, Piera-Velazquez, Poslethwaite, Ranchoux, Rieder, Strieter, Varga, Veraldi, Wells, Yoshimatsu, Zeisberg, Zeisberg   +41 more
core   +2 more sources