Results 21 to 30 of about 17,654 (241)

Common Interruptions in the Repeating Tripeptide Sequence of Non-fibrillar Collagens: Sequence Analysis and Structural Studies on Triple-helix Peptide Models [PDF]

Journal of Molecular Biology, 2008
Interruptions in the repeating (Gly-X1-X2)(n) amino acid sequence pattern are found in the triple-helix domains of all non-fibrillar collagens, and perturbations to the triple-helix at such sites are likely to play a role in collagen higher-order structure and function.
Geetha, Thiagarajan, Yingjie, Li, Angela, Mohs, Christopher, Strafaci, Magdalena, Popiel, Jean, Baum, Barbara, Brodsky   +6 more
openaire   +2 more sources

Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases. [PDF]

PLoS ONE, 2011
Hemorrhage is a clinically important manifestation of viperid snakebite envenomings, and is induced by snake venom metalloproteinases (SVMPs). Hemorrhagic and non-hemorrhagic SVMPs hydrolyze some basement membrane (BM) and associated extracellular matrix
Teresa Escalante, Natalia Ortiz, Alexandra Rucavado, Eladio F Sanchez, Michael Richardson, Jay W Fox, José María Gutiérrez   +6 more
doaj   +1 more source

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptors Functions as a Receptor Inhibitor [PDF]

, 2015
A bacterial collagen-like protein Scl2 has been developed as a recombinant collagen model system to host human collagen ligand-binding sequences, with the goal of generating biomaterials with selective collagen bioactivities.
Abbonante, V, An, B, Balduini, A, Bihan, D, Brodsky, B, Farndale, RW, Gavriilidou, D, Kaplan, D, Leitinger, B, Xu, H, Yoshizumi, A   +10 more
core   +2 more sources

Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII α1 Chain [PDF]

The American Journal of Human Genetics, 2015
The neuromuscular junction (NMJ) consists of a tripartite synapse with a presynaptic nerve terminal, Schwann cells that ensheathe the terminal bouton, and a highly specialized postsynaptic membrane. Synaptic structural integrity is crucial for efficient signal transmission.
Logan, Clare V., Cossins, Judith, Rodríguez Cruz, Pedro M., Parry, David A., Maxwell, Susan, Martínez-Martínez, Pilar, Riepsaame, Joey, Abdelhamed, Zakia A., Lake, Alice V R, Moran, Maria, Robb, Stephanie, Chow, Gabriel, Sewry, Caroline, Hopkins, Philip M., Sheridan, Eamonn, Jayawant, Sandeep, Palace, Jacqueline, Johnson, Colin A., Beeson, David   +18 more
openaire   +3 more sources

Minor Fibrillar Collagens, Variable Regions Alternative Splicing, Intrinsic Disorder, and Tyrosine Sulfation [PDF]

, 2012
Minor fibrillar collagen types V and XI, are those less abundant than the fibrillar collagens types I, II and III. The alpha chains share a high degree of similarity with respect to protein sequence in all domains except the variable region.
Fang, Ming, Jacob, Reed B., McDougal, Owen, Oxford, Julia   +3 more
core   +2 more sources

The Expression Patterns of Minor Fibrillar Collagens During Development in Zebrafish [PDF]

, 2010
Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely serve additional functions. The minor fibrillar collagens include collagens type V and type XI.
Adams, Jason S., Brown, Raquel J., Fang, Ming, Memahhan, B. Lane, Oxford, Julia   +4 more
core   +2 more sources

Stimulation of the Fibrillar Collagen and Heat Shock Proteins by Nicotinamide or Its Derivatives in Non-Irradiated or UVA Radiated Fibroblasts, and Direct Anti-Oxidant Activity of Nicotinamide Derivatives

Cosmetics, 2015
In skin aging, from intrinsic factors or exposure to ultraviolet (UV) radiation, there is loss of structural fibrillar collagen and regulatory heat shock proteins.
Neena Philips, Jovinna Chalensouk-Khaosaat, Salvador Gonzalez   +2 more
doaj   +1 more source

Collagen molecular phenotypic switch between non-neoplastic and neoplastic canine mammary tissues

Scientific Reports, 2021
In spite of major advances over the past several decades in diagnosis and treatment, breast cancer remains a global cause of morbidity and premature death for both human and veterinary patients.
Masahiko Terajima, Yuki Taga, Becky K. Brisson, Amy C. Durham, Kotaro Sato, Katsuhiro Uzawa, Tomoaki Saito, Shunji Hattori, Karin U. Sørenmo, Mitsuo Yamauchi, Susan W. Volk   +10 more
doaj   +1 more source

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Journal of Experimental & Clinical Cancer Research, 2019
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal ...
Neel I. Nissen, Morten Karsdal, Nicholas Willumsen   +2 more
doaj   +1 more source

Structural constraints on the evolution of the collagen fibril: convergence on a 1014-residue COL domain. [PDF]

, 2015
Type I collagen is the fundamental component of the extracellular matrix. Its α1 gene is the direct descendant of ancestral fibrillar collagen and contains 57 exons encoding the rod-like triple-helical COL domain. We trace the evolution of the COL domain
Farndale, Richard William, Slatter, David Anthony   +1 more
core   +3 more sources