Results 71 to 80 of about 17,654 (241)

Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]

, 2019
open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y., Bradding, Peter, Brightling, C. E., Clark, K., Gooptu, B., Roach, K.M., Smallwood, Dawn T., Stylianou, P.   +7 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

The evolution of metazoan extracellular matrix [PDF]

, 2011
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins.
Adams, Aouacheria, Ball, Barros, Bentley, Bergmeier, Boute, Chapman, Chiquet-Ehrismann, Couchman, Dehal, Engel, Ewan, Exposito, Exposito, Fahey, Gazave, Heino, Hohenester, Huhtala, Hutter, Huxley-Jones, Hynes, Hynes, Hynes, Hynes, King, King, Knack, Martindale, Merline, Myllyharju, Naba, Ozbek, Patthy, Philippe, Philippe, Pick, Putnam, Putnam, Ricard-Blum, Richard O. Hynes, Robertson, Sadler, Schaefer, Schierwater, Sebé-Pedrós, Shalchian-Tabrizi, Srivastava, Srivastava, Tucker, Wada, Whittaker, Whittaker, Yurchenco, Zhang   +55 more
core   +1 more source

Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease.
Anthony Altieri, Grace V. Visser, Matthew B. Buechler   +2 more
doaj   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

The hierarchical response of human corneal collagen to load [PDF]

, 2018
Fibrillar collagen in the human cornea is integral to its function as a transparent lens of precise curvature, and its arrangement is now well-characterised in the literature. While there has been considerable effort to incorporate fibrillar architecture
Bell, JS, Elsheikh, A, Hayes, S, Meek, KM, Sanchez-Weatherby, J, Shebanova, O, Sorensen, T, Terrill, N, Vergari, C, Whitford, C, Winlove, CP   +10 more
core   +1 more source

Hydro‐Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double‐Helical Nanostructures

Advanced Materials, EarlyView.
This paper introduces a scalable strategy for producing hierarchically aligned PBDT threads through wet‐spinning, controlled drawing, and post‐spinning twisting. Ionic crosslinking reinforces structural stability, whereas alignment and twisting optimize mechanical performance.
Woojae Jeong, Hwansoo Shin, Junho Lee, Wonsik Eom, Jeong Jae Wie, Tae Hee Han   +5 more
wiley   +1 more source

Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells. [PDF]

, 1991
Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes.
Ala-Kokko, Leena, Hyland, James, Jimenez, Sergio A., Kivirikko, Kari I., Prockop, Darwin J., Smith, Carol   +5 more
core   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source

Lung cancer-associated fibroblasts-mediated collagen deposition drives mediastinal lymph node metastasis in non-small cell lung cancer

Frontiers in Oncology
IntroductionMetastasis to mediastinal lymph nodes signifies an advanced stage of non-small cell lung cancer (NSCLC) and presents significant clinical challenges.
Caoyang Chen, Caoyang Chen, Yuqian Feng, Yuqian Feng, Frankie Chi Fat Ko, Sze Kwan Lam, Sheng Yan, James Chung Man Ho   +7 more
doaj   +1 more source