Results 81 to 90 of about 2,038,279 (256)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Disclosure of the Business Value in Financial and Non-Financial Reporting of International Corporations

Проблеми сучасних трансформацій. Серія: економіка та управління
The article highlights the features of business value disclosure in the financial and non-financial reporting of international corporations. It establishes that financial reporting provides standardized, reliable, and audit-verified data on past ...
Світлана Семенова
doaj   +1 more source

Evaluating the Effect of Organizational Culture on Non-Financial Performance through the Mediating Role of Knowledge Utilitization and Application by Using Fuzzy Network Data Envelopment Analysis (FNDEA) [PDF]

مدیریت بهره وری, 2015
This paper aims to investigate the relationship between Organizational Culture and Knowledge Utilitization and Application for ranking non-financial performance of Department of Sahand Tire Company. The main purpose of the study is presenting a model for
Mohsen shafenikabadi, Amir Salimi
doaj  

Results of non-financial corporations to 2021 Q4: preliminary year-end data

, 2022
Data from the Central Balance Sheet Data Office Quarterly Survey (CBQ) show that corporate earnings and activity increased significantly in 2021. However, the recovery was dampened in Q4 at the firms most exposed to rising energy costs. Against this background, average profitability levels rose significantly compared with 2020, albeit remaining below ...
Menéndez Pujadas, Álvaro, Mulino, Maristela   +1 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Determinants of Financial Performance Using Islamic Social Responsibility as an Intervening Variable in Sharia Commercial Banks in Indonesia

Indonesian Interdisciplinary Journal of Sharia Economics
Financial performance describes the company's financial condition in a certain period, both regarding raising funds and distributing funds, which is usually measured by capital adequacy, liquidity, and profitability indicators.
Gustin Tamara Simanungkalit, Nurlaila Nurlaila, Nur Ahmadi Bi Rahmani   +2 more
doaj   +1 more source

The quality of non-financial information in the perspective of data disclosure [PDF]

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019
openaire   +1 more source