Results 181 to 190 of about 1,440,432 (297)

Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction. [PDF]

Cell Insight
Luo J, Li Z, Shen Z, Zhai X, Chen J, Wang H, Zhao X, He J, Ding M.   +8 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Product concept design method for improving user satisfaction based on case-based reasoning. [PDF]

Sci Rep
Cheng FM, Niu XJ, Zhou X, Chen C, Dong W, Hu GR, Chen N, Liu Z.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Complications and Functional Outcomes in Open Tibia-Fibula Fractures: A Retrospective Analysis from a Tertiary Care Centre. [PDF]

J Orthop Case Rep
Kharbanda H, Kumar M, Shamim S, Singh GK.   +3 more
europepmc   +1 more source

Non-functional requirements in microservices

Microservices have recently emerged as an architectural style, gaining traction across various industries as companies transition their applications to this model. Despite the widespread adoption of microservices, research on their influence on NonFunctional Requirements (NFRs) remains limited.
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Impact of age-related maculopathy susceptibility 2, high-temperature requirement A serine peptidase 1, and complement factor H genetic variants on clinical phenotypes of age-related macular degeneration. [PDF]

Indian J Ophthalmol
Ranga D, Kaur S, Nallabelli N, Sharma SP, Tigari B, Dogra M, Katoch D, Sharma SK, Singh R, Singh N.   +9 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Early postoperative 6-minute walk test in cardiac surgery patients: an observational study assessing safety, feasibility, and predictors of completion in India. [PDF]

Acute Crit Care
Jayaraman P, Kanagaraj P, Hittalamani S.
europepmc   +1 more source