Results 201 to 210 of about 665,168 (288)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Municipal intermediate care services in Denmark and Norway: a cross-country comparative analysis. [PDF]

Scand J Prim Health Care
Udesen SEJ, Sogstad MKR, Veenstra M, Lassen AT, Skinner MS.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Quality Evaluation Considerations for Stem Cell-Derived Extracellular Vesicles-Based Therapeutic Products in China. [PDF]

J Extracell Vesicles
Na T, Zhang K, Zhao L, Yao X, Xu C, Zhang Y, Wang L, Xu M, Zhang H, Meng S.   +9 more
europepmc   +1 more source

SDK4ED Non-Functional Requirements

Non-Functional requirements pertaining to energy consumption, software complexity and dependability of the software systems targeted by the SDK4ED ecosystem. The updated version will be released in M18.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ethical-Regulatory Guidelines for AI in Palliative Care Rehabilitation. [PDF]

Healthcare (Basel)
Oliveira D, Nunes SB, Rego F, Nunes R.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cognitive-motor network integration as a behavioral marker of cognitive reserve in post-stroke rehabilitation. [PDF]

Front Neurol
Kreiger K, Weiss E, Fluri F.
europepmc   +1 more source

Non-functional requirements in microservices

Microservices have recently emerged as an architectural style, gaining traction across various industries as companies transition their applications to this model. Despite the widespread adoption of microservices, research on their influence on NonFunctional Requirements (NFRs) remains limited.
openaire   +1 more source