Results 51 to 60 of about 10,691,131 (254)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

'Post-1994 challenges facing South African NGOs : a case study of six Western Cape Non-Governmental Organizations that have a development focus' [PDF]

, 2010
Includes bibliographical references (leaves 92-104).This study examines post-1994 challenges facing six Western Cape NGOs with a development focus in South Africa.
Chimangafisi, Lemekeza
core   +1 more source

NGO impact on ensuring the quality of higher education in departmental HEIs

Університети і лідерство, 2020
The process of higher education quality assurance is a strategic priority for the development of higher education in Ukraine. To meet the EHEA standards in the sphere of higher education for the Ukrainian HEIS to cooperate with European ones; the ...
Kateryna Tryma, Natalia Salnikova
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Stretching between learning and accountability: Experiences of South African non-governmental organisations

African Evaluation Journal, 2016
This article contributes to knowledge around organisational learning in relation to Monitoring and Evaluation (M&E) processes of non-governmental organisations (NGOs).
Dzvinka Kachur, Sue Soal, Rubert Van Blerk   +2 more
doaj   +1 more source

Portrayal Of Sustainable Development Goals Through Non Governmental Organisations

, 2022
Sustainable development relies on three main sectors: government, the business sector, and non-governmental organisations. Improvements in sustainable development can only be made via the joint efforts of government, the business sector, and non ...
Juhi Gupta, Dr. Ritu Bakshi
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Identifying the Main Problems of Environmental Non-Governmental Organisations: Lessons from Romania

Present Environment and Sustainable Development, 2016
Romanian environmental non-governmental organisations (ENGO) have to deal with a lot of issues when performing their activities, related in general to their form of organization, financial capacity, unspecialized workforce, over bureaucratic ...
Apostoaie Constantin-Marius, Ionce Ruxandra   +1 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source