Results 231 to 240 of about 392,989 (308)

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Engaging communities, modeling systems: lessons from system dynamics modeling on maternal health in Texas. [PDF]

Front Glob Womens Health
Brown KK, Lemke MK, Robinson D, Fallah-Fini S, Lounsbury DW, Lambert T, Obasanya MJ, Kindratt TB.   +7 more
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Mapping stakeholders, services, data, and the information system for adolescent health in the West Bank. [PDF]

Reprod Health
Shalash A, Nemer M, Abu-Rmeileh N, Kittaneh M, Kelly D, Elmusharaf K.   +5 more
europepmc   +1 more source

New modes of governance an EU structural and cohesion policy in Estonia, Latvia and Lithuania [PDF]

, 2005
Artner, Annamaria
core  

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Changes in chronic disease prevention resources and activities in Canada during the COVID-19 pandemic. [PDF]

Health Promot Chronic Dis Prev Can
Maximova K, Marashi M, Holmes E, Mowat DL, Penney G, Paradis G, O'Loughlin JL.   +6 more
europepmc   +1 more source

IFP at a glance: results of the evaluation [PDF]

, 2012
Enders, J.
core   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Evaluation of social protection for people affected by tuberculosis: development of an indicator matrix for Brazil. [PDF]

BMC Public Health
Ferreira MRL, de Abreu PD, Maurin VP, Andrade-Gonçalves RLP, Arakawa T, de Almeida Ballestero JG, Arcêncio RA, Fronteira I, Monroe AA.   +8 more
europepmc   +1 more source