Results 121 to 130 of about 29,309,204 (245)

Evidence for changing lipid management strategy to focus on non-high density lipoprotein cholesterol

Lipids in Health and Disease, 2019
Low-density lipoprotein cholesterol (LDL-C) has been recommended as the primary treatment target on lipid management in coronary heart disease (CHD) patients for past several decades.
Xin Su, Yi Kong, Daoquan Peng
doaj   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Association Between Lipid-Lowering Therapy and Differences in the Distribution of LDL-C, apoB and non-HDL-C

Journal of Clinical Medicine
Background: The diagnosis of hypercholesterolemia relies on the laboratory assessment of lipid parameters. This study aimed to evaluate differences in the distribution of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B (apoB) concentrations according to the presence and type of ...
Marcin Ziółkowski, Karolina Obońska, Jakub Ratajczak, Piotr Adamski, Maciej Banach, Krzysztof Chlebus, Klaudyna Grzelakowska, Piotr Jankowski, Magdalena Krintus, Jacek Kryś, Ewa Laskowska, Natalia Mrzywka, Piotr Niezgoda, Małgorzata Ostrowska, Przemysław Podhajski, Grzegorz Skonieczny, Bożena Sosnowska, Łukasz Szarpak, Małgorzata Topolska, Julia Umińska, Alicja Rzepka-Cholasińska, Eliano Pio Navarese, Jacek Kubica   +22 more
openaire   +2 more sources

Regression models for concentrations of serum total, HDL, LDL, non HDL cholesterol and triglycerides and the cholesterol LDL-C/HDL-C ratio.

, 2014
1B reflects the change in the log-transformed outcome variable for each 1-unit changes in the independent variable.Model 1: adjusted for baseline value of the dependent variable, BMI, age and statin use.Model 2: adjusted for baseline value of the ...
Markku J. Savolainen (144263), Rikard Landberg (648688), Fredrik Rosqvist (648691), Matti Uusitupa (89892), Björn Åkesson (648690), Ola Kally Magnusdottir (648687), Kjeld Hermansen (328513), Lea Brader (648693), Karl-Heinz Herzig (115070), Ursula Schwab (93806), Ulf Risérus (177224), Inga Thorsdottir (308843), Lieselotte Cloetens (648689), Janne Hukkanen (648692), Ingibjorg Gunnarsdottir (308840), Marjukka Kolehmainen (93808), Kaisa Poutanen (157351)   +16 more
core   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Incremental Predictive Value of the Non-HDL-C/HDL-C Ratio for Cryptogenic Stroke in Patients with Patent Foramen Ovale

Journal of Cardiovascular Development and Disease
Background: The non-high-density lipoprotein cholesterol (non-HDL-C) / high-density lipoprotein cholesterol (HDL-C) ratio has emerged as a marker of residual vascular risk; however, its role in patent foramen ovale (PFO)-associated cryptogenic stroke (CS)
Tarik Yildirim, Mehmet Tolga Hekim, Tuncay Kiris   +2 more
doaj   +1 more source

Indices of Systemic Inflammation Are Elevated in Women With Evidence of Metabolic Syndrome After Anterior Cruciate Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To investigate the association between metabolic syndrome (MetSy) and systemic indices of the immune system and inflammation after anterior cruciate ligament reconstruction (ACLR). Methods This retrospective study included adult patients (≥18 years) who underwent ACLR at a single academic institution between 2009 and 2022.
Marina Abdelshahid, Sonu Bae, Hayden Price, Hawraa Al Janabi, Catherine Rock, Anthony Mantor, Nicholas Apseloff, Christopher C. Kaeding, Robert A. Magnussen, David C. Flanigan, Tyler Barker   +10 more
wiley   +1 more source