Results 91 to 100 of about 133,265 (260)

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor, Oishee Bandyopadhyay, Nahian Ahmed, Kapishan Shanmugathasan, Alice Cotton, ChingHao Chen, Tet Yap   +6 more
wiley   +1 more source

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source

Prognostic role of PET/CT volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International SEARCH for CAYAHL Group

British Journal of Haematology, EarlyView.
A visual overview of the key findings from the 35 papers included in this systematic review evaluating the use of PET volumetric parameters in children, adolescents and young adults with Hodgkin lymphoma. Summary In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification.
S. Claire Gowdy, Jamie E. Flerlage, Jennifer Seelisch, Monica Palese, Tyler Bradshaw, Sharon M. Castellino, Steve Cho, Karin Dieckmann, Bradford S. Hoppe, Scott Howard, Kara M. Kelly, Lars Kurch, Hollie A. Lai, Egesta Lopci, John T. Lucas Jr., Christine Mauz‐Körholz, Kathleen M. McCarten, Neeta Pandit‐Taskar, Heiko Schöder, Jonas Steglich, Dietrich Stoevesandt, Stephan D. Voss, Sarah A. Milgrom   +22 more
wiley   +1 more source

Clonal haematopoiesis in T‐follicular helper cell lymphoma: A prognostic biomarker and early event in lymphoma evolution

British Journal of Haematology, EarlyView.
Summary T‐follicular helper cell lymphomas (TFHLs) are frequently associated with epigenetic mutations and clonal haematopoiesis (CH), but the clinical and prognostic implications of CH in TFHL remains unclear. We performed next‐generation sequencing on paired peripheral blood (PB) and tumour tissue samples from 30 patients with TFHL. CH was defined by
Chong Wei, Yan Zhang, Danqing Zhao, Wei Zhang, Daobin Zhou   +4 more
wiley   +1 more source

Efficacy of immune checkpoint inhibitors in paediatric, adolescent and young adults with primary refractory or relapsed classical Hodgkin lymphoma: A national multicentre real‐world study

British Journal of Haematology, EarlyView.
Summary Classical Hodgkin lymphoma (cHL) is the most frequent lymphoma in children, adolescents and young adults (CAYA). Despite therapeutic advances, around 15% of patients relapse or have refractory (R/R) disease. Conventional salvage regimens remain effective but are associated with substantial long‐term toxicity. Immune checkpoint inhibitors (CPIs),
Marlène Pouthier, Nathalie Garnier, Amaury Leruste, Charlotte Rigaud, Catherine Curtillet, Stéphane Ducassou, Marilyne Poirée, Marie‐Emilie Dourthe, Cécile Pochon, Marie‐Laure Couec, Jacinthe Bonneau‐Lagacherie, Françoise Montravers, Sabah Boudjemaa, Bénédicte Jonca, Stéphanie Haouy, Thierry Leblanc, Judith Landman Parker, Mathieu Simonin   +17 more
wiley   +1 more source

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

Prognostic impact of treatment‐related and geriatric factors in older patients with classic Hodgkin lymphoma: A real‐life cohort study

British Journal of Haematology, EarlyView.
Summary Older patients with classic Hodgkin lymphoma experience poorer outcomes than younger individuals, due to comorbidities and functional limitations affecting treatment tolerance. In this retrospective single‐centre study of 140 patients, we evaluated treatment patterns, outcomes and the prognostic value of two geriatric scores: the Age ...
Silvio Ligia, Giovanni Manfredi Assanto, Tania Soriano, Luca Vincenzo Cappelli, Mauro Passucci, Giorgia Annechini, Gianna Maria D'Elia, Alessandro Pulsoni, Maurizio Martelli, Ilaria Del Giudice   +9 more
wiley   +1 more source

Mycosis fungoides and Sézary syndrome

British Journal of Haematology, EarlyView.
Summary Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T‐cell lymphomas, arising from mature CD4+ memory T cells. Diagnosis is complex and relies on clinicopathological correlation, immunophenotyping and molecular clonality testing, while management is stage‐adapted, with potentially curative outcomes achievable only in ...
Francisco Martins, Joana Calvão
wiley   +1 more source