Results 271 to 280 of about 237,923 (376)

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar, Chadwick W. Christine, Nicolás Phielipp, Paul S. Larson, J. Bradley Elder, Aristide Merola, Waldy San Sebastian, Massimo S. Fiandaca, Adrian P. Kells, Michael E. Wisniewski, Krystof S. Bankiewicz   +10 more
wiley   +1 more source

Long lasting argon neuroprotection in a non-human primate model of transient endovascular ischemic stroke. [PDF]

J Cereb Blood Flow Metab
González Torrecilla S, Delbrel A, Giacomino L, Meunier D, Sein J, Renaud L, Brige P, Garrigue P, Hak JF, Guillet B, Brunel H, Farjot G, Brochier T, Velly L.   +13 more
europepmc   +1 more source

Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study

, 2003
Thomas S. Deisboeck, Hiroaki Wakimoto, Ulf Nestler, David N. Louis, Prabhat K. Sehgal, Meredith A. Simon, E. Antonio Chiocca, F. Hochberg   +7 more
openalex   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Advantages and challenges of using allogeneic vs. autologous sources for neuronal cell replacement in Parkinson's disease: Insights from non-human primate studies. [PDF]

Brain Res Bull
Emborg ME, Metzger JM, D'Amour K, Colwell JC, Neumann LC, Zhang A, Federoff HJ.   +6 more
europepmc   +1 more source

Corticospinal Tract Development, Evolution, and Skilled Movements

Movement Disorders, EarlyView.
Abstract The evolution of the corticospinal tract (CST) is closely linked to the development of skilled voluntary movements in mammals. The main evolutionary divergence concerns the position of the CST within the spinal cord white matter and its postsynaptic targets in the grey matter.
Emmanuel Roze, Caroline Dubacq, Quentin Welniarz   +2 more
wiley   +1 more source

Transcriptomic and genetic profiling in a spontaneous non-human primate model of hypertrophic cardiomyopathy and sudden cardiac death. [PDF]

Sci Rep
Rivas VN, Vandewege MW, Ueda Y, Kaplan JL, Reader J, Roberts JA, Stern JA.   +6 more
europepmc   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Complete genome sequence of a virulent barcoded <i>Mycobacterium tuberculosis</i> str. Erdman commonly used for non-human primate infection studies. [PDF]

Microbiol Resour Announc
Marin MG, Chase MR, Quinones N, Wakabayashi S, Mugahid D, Fortune SM, Farhat MR, Chao MC.   +7 more
europepmc   +1 more source

Nonlocal Cooperative Behavior, Psychological Effects, and Collective Decision‐Making: An Exemplification With Predator–Prey Models

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In bio‐social models, cooperative behavior has evolved as an adaptive strategy, playing multi‐functional roles. One of such roles in populations is to increase the success of the survival and reproduction of individuals and their families or social groups.
Sangeeta Saha, Swadesh Pal, Roderick Melnik   +2 more
wiley   +1 more source