Results 291 to 300 of about 237,923 (376)

Interactions of Therapeutic Antibodies With Presynaptically‐Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte‐Carlo Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferent neuron.
Jamie Goff, Maryam Khalifa, Shaina M. Short, Piet H. van der Graaf, Hugo Geerts   +4 more
wiley   +1 more source

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts. [PDF]

Nat Cardiovasc Res
Ruiz-Orera J, Miller DC, Greiner J, Genehr C, Grammatikaki A, Blachut S, Mbebi J, Patone G, Myronova A, Adami E, Dewani N, Liang N, Hummel O, Muecke MB, Hildebrandt TB, Fritsch G, Schrade L, Zimmermann WH, Kondova I, Diecke S, van Heesch S, Hübner N.   +21 more
europepmc   +1 more source

A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA Vaccines

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The unprecedented effort to cope with the COVID‐19 pandemic has unlocked the potential of mRNA vaccines as a powerful technology, set to become increasingly pervasive in the years to come. As in other areas of drug development, mathematical modeling is a pivotal tool to support and expedite the mRNA vaccine development process.
Lorenzo Dasti, Stefano Giampiccolo, Elisa Pettinà, Giada Fiandaca, Natascia Zangani, Lorena Leonardelli, Fabio De Lima Hedayioglu, Elio Campanile, Luca Marchetti   +8 more
wiley   +1 more source

Occurrence of Free-Living Amoebae in Non-Human Primate Gut. [PDF]

Trop Med Infect Dis
Cardoso IR, de Lima CS, Dos Reis RB, Pinto ACA, Pissinatti T, Kugelmeier T, Neto SFDC, da Silva FA, Santos HLC.   +8 more
europepmc   +1 more source

Viral Dynamic Models During COVID‐19: Are We Ready for the Next Pandemic?

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the natural history of acute SARS‐CoV‐2 infection, optimize antiviral treatment strategies, understand factors ...
Aurelien Marc, Joshua T. Schiffer, France Mentré, Alan S. Perelson, Jérémie Guedj   +4 more
wiley   +1 more source

Mapping oil palm plantations and their implications on forest and great ape habitat loss in Central Africa

Remote Sensing in Ecology and Conservation, EarlyView.
This paper takes a retrospective look at the changes in the extent of the Congo forest and great ape habitat in the past 20 years. The data and method used in this study are novel. This produced the very first Central Africa ‐specific oil palm extent and forest change dynamics, highlighting a great ape habitat and species range decline.
Mohammed S. Ozigis, Serge Wich, Adrià Descals, Zoltan Szantoi, Erik Meijaard   +4 more
wiley   +1 more source

Cerebral Angiography and Neurobehavioral Patterns in a Non-human Primate Middle Cerebral Artery Occlusion Model. [PDF]

In Vivo
Yoshikawa T, Akiyoshi Y, Motokawa K, Nojiri K, Kawaguchi H.   +4 more
europepmc   +1 more source

The secret acoustic world of leopards: A paired camera trap and bioacoustics survey facilitates the individual identification of leopards via their roars

Remote Sensing in Ecology and Conservation, EarlyView.
Here, we conducted the first large‐scale joint camera trap and bioacoustics survey for large African carnivores in Nyerere National Park, Tanzania. By combining the different data types that each technology produced, this led to the discovery that every leopard has a unique, identifiable roar which enables leopards to be the focus of other, more ...
Jonathan Growcott, Alex Lobora, Andrew Markham, Charlotte E. Searle, Johan Wahlström, Matthew Wijers, Benno I. Simmons   +6 more
wiley   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Long-term tracking of haematopoietic clonal dynamics and mutations in non-human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells. [PDF]

Br J Haematol
Hosuru RV, Yang J, Zhou Y, Gin A, Hayal TB, Hong SG, Dunbar CE, Wu C.   +7 more
europepmc   +1 more source