Results 231 to 240 of about 317,227 (291)

An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates. [PDF]

EBioMedicine
Cummings BB, Bouchard PR, Milton MN, Moesta PF, Ramanan V, Trauger JW, Maratos-Flier E, Voznesensky A, Splawski I, Nimonkar AV, DiPetrillo K, LaSala D, Pan M, Flaherty MM, Huet F, Sahambi SK, Dong J, Knee D, Cebe R, Huber T, Lehrer-Graiwer J, Juliano RA, Weiss EJ.   +22 more
europepmc   +1 more source

One‐Stone‐Two‐Birds Carrier‐Free Nano‐Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment

Exploration, EarlyView.
ABSTRACT Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non‐stem cancer cells. Herein, we propose a cancer cells/CSCs double‐killing modality
Tongyao Zhao, Yao Chen, Haimeng Yuan, Shuqian Yang, Hongyuan Zhang, Yuequan Wang, Shenwu Zhang, Qin Chen, Jin Sun, Zhonggui He, Cong Luo   +10 more
wiley   +1 more source

First molecular evidence of <i>Hepatocystis</i> infection in non-human primates from Indonesia using fecal DNA: Implications for wildlife surveillance and One Health. [PDF]

Vet World
Hasan F, Siregar JE, Pravitasari NE, Rizki AFM, Azmi WA, Artika IM, Kuswanda W.   +6 more
europepmc   +1 more source

One‐Stone‐Three‐Birds Biomimetic Oral Targeting Delivery Strategy for On‐Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy

Exploration, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a multifactorial condition characterized by excessive inflammation, immune dysfunction, and metabolic disorders. Current therapeutic strategies primarily rely on local injection, a traumatic approach associated with risks of tissue damage and infection.
Yifan Ding, Yixin Cai, Weizhen Pan, Na Hu, Yunyun Wang, Huan Wang, Huang Fang, Songwei Tan, Zhiping Zhang   +8 more
wiley   +1 more source

Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates. [PDF]

Brain Sci
Sinopoulou E, Chow MW, Obaid N, Chong E, Nout-Lomas YS, Wurr R, Macon R, Huie JR, Ferguson AR, Tuszynski MH, Beattie MS, Bresnahan JC, Sparrey CJ.   +12 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Mapping the antibody response to Lassa virus vaccination of non-human primates. [PDF]

EBioMedicine
Enriquez AS, Avalos RD, Parekh D, Cooper CL, Morrow G, Geisbert TW, Parks CL, Hastie KM, Saphire EO.   +8 more
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates. [PDF]

J Neural Eng
Forrest AM, Kunigk NG, Collinger JL, Gaunt RA, Chen X, Vande Geest JP, Kozai TDY.   +6 more
europepmc   +1 more source

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

International Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch, Ana Carolina Rodrigues, Priscila Elias Ferreira Stricker, Alexandre Luiz Korte Azevedo, Daniel Pacheco Bruschi, Jaqueline Carvalho de Oliveira   +5 more
wiley   +1 more source