Results 61 to 70 of about 11,648,645 (304)

Associations between flow in paratibial perforating veins and great saphenous vein patterns of reflux

Veins and Lymphatics, 2015
Perforating veins contribute to chronic venous valvular insufficiency (CVVI, subset of CVI) of lower extremities (LE). We investigated the role of medial, proximal calf paratibial perforating veins (PTPV).
Carlos Alberto Engelhorn, Ana Luiza Dias Valiente Engelhorn, Sergio Xavier Salles-Cunha, Nicolle Amboni Schio, Giovanna Golin Guarinello, Bruna Orlandoski Erbano   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Non-invasive Neuromodulation of Arrhythmias

Cardiac Electrophysiology Clinics
The autonomic nervous system plays a central role in the pathogenesis of arrhythmias. Preclinical and clinical studies have demonstrated the therapeutic effect of neuromodulation at multiple anatomic targets across the neurocardiac axis for the treatment of arrhythmias.
Farhat, Kassem, Po, Sunny S., Stavrakis, Stavros   +2 more
openaire   +3 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Drug efficacy of ivermectin against primary nematodes parasitizing captive Przewalski’s horse (Equus ferus przewalskii) after ten years of annually treatment

Helminthologia, 2020
Reintroduction of endangered species to natural habitat is considered as an important tool for conservation. The effect of drug management on captive population of reintroduced species is largely neglected.
Tang L., Xiu Y., Yan L., Cui Y., Ma X., Ente M., Zhang Y., Li K., Zhang D.   +8 more
doaj   +1 more source

The impact of temperature on the life cycle of Gasterophilus pecorum in northwest China

Parasites & Vectors, 2021
Background The departure of the mature larvae of the horse stomach bot fly from the host indicates the beginning of a new infection period. Gasterophilus pecorum is the dominant bot fly species in the desert steppe of the Kalamaili Nature Reserve (KNR ...
Ke Zhang, Heqing Huang, Ran Zhou, Boru Zhang, Chen Wang, Make Ente, Boling Li, Dong Zhang, Kai Li   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Safety and Feasibility of Ultrasound-Guided Access for Coronary Interventions through Distal Left Radial Route

Journal of Interventional Cardiology, 2022
Aims. Left distal transradial arterial approach (ldTRA) is a new interventional route that spares right radial artery (RRA) for use in haemodialysis and as bypass graft.
Tapan Ghose, Ranjan Kachru, Jaideep Dey, Wasi Ullah Khan, Ratna Sud, Suraiya Jabeen, Shahnawaz Husain, Aparna Pant   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source